DGKD and TNFRSF14

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DGKD	TNFRSF14
Gene Name		diacylglycerol kinase, delta 130kDa	tumor necrosis factor receptor superfamily, member 14
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cytoplasmic Membrane-bounded Vesicle	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Diacylglycerol Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Blood Coagulation Response To Organic Substance Protein Transport Cell Growth Phosphorylation Second-messenger-mediated Signaling Platelet Activation Diacylglycerol Metabolic Process Protein Homooligomerization	Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway Response To Virus Viral Process T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Migration
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis	Costimulation by the CD28 family Adaptive Immune System
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Calcium levels ( 20705733) Crohn's disease ( 22412388)	Celiac disease ( 20190752) Rheumatoid arthritis ( 18794853 20453842) Ulcerative colitis ( 23128233 21297633)
Protein-Protein Interactions		7 interactors: DGKH HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	30 interactors: A2M APP BTLA CD160 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 KIAA1377 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		8527	8764
HPRD ID		03492	04122
Ensembl ID		ENSG00000077044	ENSG00000157873
Uniprot IDs		Q16760	Q92956
PDB IDs		1R79 3BQ7	1JMA 2AW2 4FHQ
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Immune System Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Wound Healing Regulation Of Myeloid Leukocyte Differentiation Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Response To Wounding Histone H3-T6 Phosphorylation Response To Cytokine Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Localization Regulation Of Myeloid Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Cytokine Secretion Involved In Immune Response Platelet Activation Positive Regulation Of Protein Modification Process Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Plasma Membrane Repair Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Granulocyte Differentiation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Degradation Negative Regulation Of Glucose Import Positive Regulation Of Cell Migration Immune Response Positive Regulation Of Cell Motility Regulation Of Phosphorylation Positive Regulation Of Macrophage Differentiation Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Cellular Component Movement Defense Response Desmosome Organization Positive Regulation Of Locomotion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway	Signal Transduction Apoptotic Process Programmed Cell Death Signaling Cell Communication Cell Death Death Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteolysis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Regulation Of Endopeptidase Activity Regulation Of Immune System Process Regulation Of Peptidase Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription Factor Import Into Nucleus Response To Stress Negative Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cell Activation Histone H4 Deacetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Proteolysis Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Histone H3 Deacetylation Negative Regulation Of Protein Processing Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization
Tagcloud ?			aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Difference) ?			aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Intersection) ?