DGKD

Gene Name		diacylglycerol kinase, delta 130kDa
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Diacylglycerol Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Blood Coagulation Response To Organic Substance Protein Transport Cell Growth Phosphorylation Second-messenger-mediated Signaling Platelet Activation Diacylglycerol Metabolic Process Protein Homooligomerization
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Calcium levels ( 20705733) Crohn's disease ( 22412388)
Protein-protein Interactions		7 interactors: DGKH HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14
Entrez ID		8527
HPRD ID		03492
Ensembl ID		ENSG00000077044
Uniprot IDs		Q16760
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Immune System Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Wound Healing Regulation Of Myeloid Leukocyte Differentiation Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Response To Wounding Histone H3-T6 Phosphorylation Response To Cytokine Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Localization Regulation Of Myeloid Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Cytokine Secretion Involved In Immune Response Platelet Activation Positive Regulation Of Protein Modification Process Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Plasma Membrane Repair Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Granulocyte Differentiation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Degradation Negative Regulation Of Glucose Import Positive Regulation Of Cell Migration Immune Response Positive Regulation Of Cell Motility Regulation Of Phosphorylation Positive Regulation Of Macrophage Differentiation Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Cellular Component Movement Defense Response Desmosome Organization Positive Regulation Of Locomotion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway
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