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USP7 and RB1
Number of citations of the paper that reports this interaction (PubMedID
24823443
)
58
Data Source:
BioGRID
(enzymatic study)
USP7
RB1
Description
ubiquitin specific peptidase 7
RB transcriptional corepressor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Nuclear Body
PML Body
Protein-containing Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Spindle
Cytosol
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Chromatin Lock Complex
Molecular Function
P53 Binding
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Deubiquitinase Activity
K48-linked Deubiquitinase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Biological Process
Autophagosome Assembly
DNA Repair
Transcription-coupled Nucleotide-excision Repair
DNA Alkylation Repair
Proteolysis
DNA Damage Response
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
TORC1 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of Gluconeogenesis
Rhythmic Process
Protein Stabilization
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Establishment Of Protein Localization To Telomere
Symbiont-mediated Disruption Of Host Cell PML Body
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Regulation Of Telomere Capping
Regulation Of Retrograde Transport, Endosome To Golgi
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Tissue Homeostasis
Chondrocyte Differentiation
Aortic Valve Morphogenesis
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Smoothened Signaling Pathway
Ras Protein Signal Transduction
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Glial Cell Proliferation
Cell Differentiation
Neuron Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Heterochromatin Formation
Developmental Process
Cellular Response To Insulin Stimulus
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Negative Regulation Of Glial Cell Proliferation
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Nuclear events stimulated by ALK signaling in cancer
Positive Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
Chronic myeloid leukemia (CML)
Breast cancer
Osteosarcoma
Hepatocellular carcinoma
Small cell lung cancer
Esophageal cancer
Glioma
Bladder cancer
GWAS
Appendicular lean mass (
33097823
)
Chronotype (
30696823
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Birth weight (
27680694
31043758
)
Chronic kidney disease (
26420894
)
Diastolic blood pressure (
34074324
)
Lymphocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
349 interacting genes:
ABCB1
ABRAXAS2
ACACB
ACD
ACLY
ADAR
ADARB1
AHNAK
AKIRIN1
ALB
ANKS1A
ANXA1
ANXA9
ARHGEF17
ARMC5
ARNT2
ASPM
ATXN1
AXIN1
BACH1
BCLAF1
BCOR
BEND5
BRPF1
BSN
CAMSAP1
CAV1
CBR1
CBX8
CCAR1
CCDC141
CCP110
CDC42BPA
CDC5L
CDR2L
CENPE
CEP250
CGNL1
CLSPN
CLTC
COBLL1
CREB3L3
CRY1
CSNK2A1
CTDP1
CTTN
DAXX
DBN1
DCD
DCTPP1
DDX17
DDX21
DDX24
DDX3X
DDX5
DDX50
DDX54
DDX60
DHX15
DHX30
DHX40
DHX9
DLST
DMD
DNAH5
DNAJA3
DNAJC16
DNHD1
DNMT3A
DSP
DST
DUSP2
DYRK1A
ECT2
EEA1
EEF1B2
EEF1D
EEF1G
EFCAB5
EFTUD2
ERCC6
ETS2
EWSR1
EXOSC10
FAM120C
FAM186A
FANCD2
FAT2
FAT3
FBXO38
FER1L6
FLG2
FMR1
FOXM1
FOXN2
FXR1
GATA1
GIGYF2
GMPS
GNL3
GOLGB1
GON4L
GRM1
GRWD1
GTF2I
GTPBP4
H2AC20
H2BC26
H2BC3
H3C1
HECW1
HERC1
HERPUD1
HMOX1
HNRNPC
HNRNPL
HNRNPM
HNRNPR
HRNR
HSPA9
HTRA2
IFNAR1
IGF2BP1
IGF2BP3
IGHG1
IKZF1
ILF3
IPCEF1
KDR
KHDRBS1
KIAA1549L
KIF13A
KLF12
KLHL5
KLHL8
KMT2D
KRI1
LAMA1
LEPR
LIMA1
LINC02582
LINGO2
LPIN3
LRBA
LTF
LTV1
LUC7L3
MACF1
MAGEE1
MAL
MARCHF7
MAST2
MATR3
MCMBP
MDC1
MDM2
MDM4
MDN1
MEX3B
MINK1
MLF2
MPRIP
MTREX
MYBBP1A
MYC
MYD88
MYH13
MYO1B
MYO5A
MYO7B
NAT10
NEB
NECAB2
NEDD4L
NGEF
NKRF
NLRP11
NOM1
NOP2
NSD1
NUMA1
OGDH
OTOF
OTUD4
OVCH1
PABPC1
PARP1
PBRM1
PC
PCARE
PCGF2
PCLAF
PDE3A
PEG3
PELP1
PEPD
PES1
PHLDB2
PICK1
PIP
PKM
PLA2G2A
PLCH1
PLEC
PLEKHO1
PLK1
PNN
PNPLA4
POLI
POP1
PPARG
PPFIA1
PPIP5K1
PPL
PPP1R12A
PRDM16
PRPF19
PRPF40A
PRPF8
PSIP1
PTEN
PWP1
RAD18
RAD50
RADIL
RAF1
RAI14
RALY
RARA
RB1
RBBP4
RBCK1
RBM15
RBM39
RCC2
RELA
RFC1
RFFL
RGPD8
RNF168
RNF220
RPL7A
RPLP0
RPS3
RPS4X
RPS6
RSL1D1
RSPH1
SALL1
SAMHD1
SAP130
SAP30BP
SCML2
SDK2
SENP1
SERBP1
SF3B1
SF3B2
SF3B3
SHOC2
SIRT5
SLC15A1
SLC38A6
SLC4A5
SLIT2
SMAD3
SMARCA4
SMARCA5
SMARCC1
SMARCC2
SNCA
SNRNP200
SNRNP70
SNX25
SOX9
SP4
SRPK1
SRRM2
SRSF4
STAU1
SUMO2
SUPT16H
SYCP1
SYNE1
SYT14
SYVN1
TANK
TBCB
TERT
TEX15
TFIP11
THOC2
THRAP3
TMPO
TNPO3
TOP2A
TOP2B
TP53
TPM4
TPR
TPX2
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM22
TRIM31
TRIM54
TRIM55
TRIM63
TRIM8
TRO
TSC22D2
TTN
U2AF2
UBA52
UBAP2
UBC
UBE2D3
UBE2E1
UBE2S
UBN1
UBTF
UHRF1
UMPS
USP21
USP28
UTP14C
UTY
VARS1
VCP
VIM
VIRMA
VPS13B
VPS35
WWP2
XPC
XRN2
YY1
ZC3HAV1
ZFR
ZGRF1
ZMYM1
ZMYND8
ZNF335
ZNF423
ZNF76
194 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FOXM1
FRK
FZR1
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KEAP1
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCF1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB1
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PPP1R9B
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIM28
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
Entrez ID
7874
5925
HPRD ID
03950
01574
Ensembl ID
ENSG00000187555
ENSG00000139687
Uniprot IDs
B7Z855
B7ZAX6
Q6U8A4
Q93009
A0A2R8YFL6
A0A3B3IS71
P06400
PDB IDs
1NB8
1NBF
1YY6
1YZE
2F1W
2F1X
2F1Y
2F1Z
2FOJ
2FOO
2FOP
2KVR
2XXN
2YLM
3MQR
3MQS
4JJQ
4KG9
4M5W
4M5X
4PYZ
4WPH
4WPI
4YOC
4YSI
4Z96
4Z97
5C56
5C6D
5FWI
5GG4
5J7T
5JTJ
5JTV
5KYB
5KYC
5KYD
5KYE
5KYF
5N9R
5N9T
5NGE
5NGF
5UQV
5UQX
5VS6
5VSB
5VSK
5WHC
6F5H
6M1K
6P5L
6VN2
6VN3
6VN4
6VN5
6VN6
7CM2
7VIJ
7XHH
7XHK
7XPY
8D4Z
9DEK
9DEL
9DEM
9DEN
9DEO
9DEP
9FIO
9FIP
9FIQ
9FIR
9FIS
9FIT
9FIU
9FIV
9IJU
9IML
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
9DGK
9DHC
9DHF
9DHU
Enriched GO Terms of Interacting Partners
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Nucleus
RNA Binding
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Nucleolus
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
RNA Processing
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
MRNA Processing
MRNA Metabolic Process
Chromatin Organization
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
Positive Regulation Of RNA Biosynthetic Process
RNA Splicing
Catalytic Step 2 Spliceosome
Positive Regulation Of DNA-templated Transcription
Nucleic Acid Binding
Cellular Response To Stress
MRNA Binding
Negative Regulation Of DNA-templated Transcription
Response To Stress
Negative Regulation Of RNA Biosynthetic Process
DNA Damage Response
DNA Metabolic Process
Chromatin Remodeling
Protein-containing Complex
Spliceosomal Complex
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Cellular Response To Stress
Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
DNA Damage Response
Chromatin
Chromatin Binding
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Programmed Cell Death
DNA-templated Transcription
Regulation Of Apoptotic Process
Macromolecule Metabolic Process
Chromatin Remodeling
Chromatin Organization
Regulation Of Mitotic Cell Cycle
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
DNA Binding
Transcription Cis-regulatory Region Binding
Nucleobase-containing Compound Metabolic Process
Response To Stress
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