USP7 and PEPD

Number of citations of the paper that reports this interaction (PMID 18330356)
4

Data Source:
BioGRID (two hybrid)

		USP7	PEPD
Gene Name		ubiquitin specific peptidase 7 (herpes virus-associated)	peptidase D
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol PML Body	Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding	Aminopeptidase Activity Metallocarboxypeptidase Activity Dipeptidase Activity Manganese Ion Binding
	Biological Process	Transcription-coupled Nucleotide-excision Repair Multicellular Organismal Development Maintenance Of DNA Methylation Viral Process Histone Deubiquitination Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process	Proteolysis Cellular Amino Acid Metabolic Process Collagen Catabolic Process
Pathways
Drugs
Diseases
GWAS			Adiponectin levels ( 22479202) Fasting insulin-related traits (interaction with BMI) ( 22581228) Type 2 diabetes ( 22158537)
Protein-Protein Interactions		85 interactors: ACD ARNT2 ATXN1 BCOR BEND5 BMI1 CBX8 CHEK1 CLSPN CREB3L3 DAXX DNAJA3 DNMT1 DNMT3A EWSR1 EZH2 FAM175B FOXN2 HECW1 HERPUD1 HIST3H2BB HTRA2 KAT5 KLHL8 MAGEE1 MAL MARCH7 MCMBP MDM2 MDM4 MYD88 NECAB2 PCGF2 PEG3 PEPD PHLDB2 PICK1 PJA1 PLA2G2A PLEKHO1 PPARG PPL RADIL RARA RB1 RBCK1 RELA RFFL RING1 RNF2 RNF220 SMAD3 SUMO1 SUZ12 SYVN1 TANK TBCB TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM27 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBC UBE2E1 UBE2S UHRF2 USP15 USP21 USP28 WWP2 XPC ZEB1 ZMYND8 ZNF423	4 interactors: ATXN1 SPP1 TERF1 USP7
Entrez ID		7874	5184
HPRD ID		03950	01358
Ensembl ID		ENSG00000187555	ENSG00000124299
Uniprot IDs		B7Z815 Q6U8A4 Q93009	P12955
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ	2IW2 2OKN
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Metabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Process Modification-dependent Protein Catabolic Process Chromosome Organization Chromatin Organization Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Transcription, DNA-templated Cellular Macromolecule Catabolic Process Apoptotic Process RNA Biosynthetic Process Programmed Cell Death Chromatin Modification Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Histone Ubiquitination Cell Death	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Proteasomal Protein Catabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Maintenance Of DNA Methylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Replicative Cell Aging Regulation Of Protein Catabolic Process Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Positive Regulation Of Bone Resorption Developmental Process Regulation Of Axon Regeneration Histone Deubiquitination Regulation Of Telomere Maintenance RNA-dependent DNA Replication Chromatin Modification Negative Regulation Of DNA Biosynthetic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Microtubule Polymerization Positive Regulation Of Tissue Remodeling Decidualization Response To Vitamin D Chromatin Organization Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Regulation Of Bone Resorption Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Maternal Placenta Development Regulation Of Bone Remodeling Regulation Of DNA Biosynthetic Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division
Tagcloud ?		accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb prkcg psg1 pw39 tnnt1
Tagcloud (Difference) ?		accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb prkcg psg1 pw39 tnnt1
Tagcloud (Intersection) ?