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USP7 and HTRA2
Number of citations of the paper that reports this interaction (PubMedID
16713569
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
USP7
HTRA2
Description
ubiquitin specific peptidase 7
HtrA serine peptidase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Nuclear Body
PML Body
Protein-containing Complex
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Molecular Function
P53 Binding
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin Ligase Inhibitor Activity
Biological Process
Autophagosome Assembly
DNA Repair
Transcription-coupled Nucleotide-excision Repair
DNA Alkylation Repair
Proteolysis
DNA Damage Response
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
TORC1 Signaling
Regulation Of Circadian Rhythm
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of Gluconeogenesis
Rhythmic Process
Protein Stabilization
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Establishment Of Protein Localization To Telomere
Symbiont-mediated Disruption Of Host Cell PML Body
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Regulation Of Telomere Capping
Regulation Of Retrograde Transport, Endosome To Golgi
Proteolysis
Ceramide Metabolic Process
Apoptotic Process
Mitochondrion Organization
Adult Walking Behavior
Adult Locomotory Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Protein Catabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Intracellular Signal Transduction
Mitochondrial Protein Catabolic Process
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Neuron Development
Neuron Apoptotic Process
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Type 2 Mitophagy
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization
Mitochondrial protein degradation
Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Appendicular lean mass (
33097823
)
Chronotype (
30696823
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Interacting Genes
349 interacting genes:
ABCB1
ABRAXAS2
ACACB
ACD
ACLY
ADAR
ADARB1
AHNAK
AKIRIN1
ALB
ANKS1A
ANXA1
ANXA9
ARHGEF17
ARMC5
ARNT2
ASPM
ATXN1
AXIN1
BACH1
BCLAF1
BCOR
BEND5
BRPF1
BSN
CAMSAP1
CAV1
CBR1
CBX8
CCAR1
CCDC141
CCP110
CDC42BPA
CDC5L
CDR2L
CENPE
CEP250
CGNL1
CLSPN
CLTC
COBLL1
CREB3L3
CRY1
CSNK2A1
CTDP1
CTTN
DAXX
DBN1
DCD
DCTPP1
DDX17
DDX21
DDX24
DDX3X
DDX5
DDX50
DDX54
DDX60
DHX15
DHX30
DHX40
DHX9
DLST
DMD
DNAH5
DNAJA3
DNAJC16
DNHD1
DNMT3A
DSP
DST
DUSP2
DYRK1A
ECT2
EEA1
EEF1B2
EEF1D
EEF1G
EFCAB5
EFTUD2
ERCC6
ETS2
EWSR1
EXOSC10
FAM120C
FAM186A
FANCD2
FAT2
FAT3
FBXO38
FER1L6
FLG2
FMR1
FOXM1
FOXN2
FXR1
GATA1
GIGYF2
GMPS
GNL3
GOLGB1
GON4L
GRM1
GRWD1
GTF2I
GTPBP4
H2AC20
H2BC26
H2BC3
H3C1
HECW1
HERC1
HERPUD1
HMOX1
HNRNPC
HNRNPL
HNRNPM
HNRNPR
HRNR
HSPA9
HTRA2
IFNAR1
IGF2BP1
IGF2BP3
IGHG1
IKZF1
ILF3
IPCEF1
KDR
KHDRBS1
KIAA1549L
KIF13A
KLF12
KLHL5
KLHL8
KMT2D
KRI1
LAMA1
LEPR
LIMA1
LINC02582
LINGO2
LPIN3
LRBA
LTF
LTV1
LUC7L3
MACF1
MAGEE1
MAL
MARCHF7
MAST2
MATR3
MCMBP
MDC1
MDM2
MDM4
MDN1
MEX3B
MINK1
MLF2
MPRIP
MTREX
MYBBP1A
MYC
MYD88
MYH13
MYO1B
MYO5A
MYO7B
NAT10
NEB
NECAB2
NEDD4L
NGEF
NKRF
NLRP11
NOM1
NOP2
NSD1
NUMA1
OGDH
OTOF
OTUD4
OVCH1
PABPC1
PARP1
PBRM1
PC
PCARE
PCGF2
PCLAF
PDE3A
PEG3
PELP1
PEPD
PES1
PHLDB2
PICK1
PIP
PKM
PLA2G2A
PLCH1
PLEC
PLEKHO1
PLK1
PNN
PNPLA4
POLI
POP1
PPARG
PPFIA1
PPIP5K1
PPL
PPP1R12A
PRDM16
PRPF19
PRPF40A
PRPF8
PSIP1
PTEN
PWP1
RAD18
RAD50
RADIL
RAF1
RAI14
RALY
RARA
RB1
RBBP4
RBCK1
RBM15
RBM39
RCC2
RELA
RFC1
RFFL
RGPD8
RNF168
RNF220
RPL7A
RPLP0
RPS3
RPS4X
RPS6
RSL1D1
RSPH1
SALL1
SAMHD1
SAP130
SAP30BP
SCML2
SDK2
SENP1
SERBP1
SF3B1
SF3B2
SF3B3
SHOC2
SIRT5
SLC15A1
SLC38A6
SLC4A5
SLIT2
SMAD3
SMARCA4
SMARCA5
SMARCC1
SMARCC2
SNCA
SNRNP200
SNRNP70
SNX25
SOX9
SP4
SRPK1
SRRM2
SRSF4
STAU1
SUMO2
SUPT16H
SYCP1
SYNE1
SYT14
SYVN1
TANK
TBCB
TERT
TEX15
TFIP11
THOC2
THRAP3
TMPO
TNPO3
TOP2A
TOP2B
TP53
TPM4
TPR
TPX2
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM22
TRIM31
TRIM54
TRIM55
TRIM63
TRIM8
TRO
TSC22D2
TTN
U2AF2
UBA52
UBAP2
UBC
UBE2D3
UBE2E1
UBE2S
UBN1
UBTF
UHRF1
UMPS
USP21
USP28
UTP14C
UTY
VARS1
VCP
VIM
VIRMA
VPS13B
VPS35
WWP2
XPC
XRN2
YY1
ZC3HAV1
ZFR
ZGRF1
ZMYM1
ZMYND8
ZNF335
ZNF423
ZNF76
41 interacting genes:
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
ITGA7
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PDXDC2P-NPIPB14P
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
UBC
USP7
VIM
VPS4B
XIAP
Entrez ID
7874
27429
HPRD ID
03950
05919
Ensembl ID
ENSG00000187555
ENSG00000115317
Uniprot IDs
B7Z855
B7ZAX6
Q6U8A4
Q93009
A0A384MDW9
A0A8Q3SIX7
O43464
PDB IDs
1NB8
1NBF
1YY6
1YZE
2F1W
2F1X
2F1Y
2F1Z
2FOJ
2FOO
2FOP
2KVR
2XXN
2YLM
3MQR
3MQS
4JJQ
4KG9
4M5W
4M5X
4PYZ
4WPH
4WPI
4YOC
4YSI
4Z96
4Z97
5C56
5C6D
5FWI
5GG4
5J7T
5JTJ
5JTV
5KYB
5KYC
5KYD
5KYE
5KYF
5N9R
5N9T
5NGE
5NGF
5UQV
5UQX
5VS6
5VSB
5VSK
5WHC
6F5H
6M1K
6P5L
6VN2
6VN3
6VN4
6VN5
6VN6
7CM2
7VIJ
7XHH
7XHK
7XPY
8D4Z
9DEK
9DEL
9DEM
9DEN
9DEO
9DEP
9FIO
9FIP
9FIQ
9FIR
9FIS
9FIT
9FIU
9FIV
9IJU
9IML
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
7VGE
8AUK
8E2K
Enriched GO Terms of Interacting Partners
?
Nucleus
RNA Binding
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Nucleolus
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
RNA Processing
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
MRNA Processing
MRNA Metabolic Process
Chromatin Organization
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
Positive Regulation Of RNA Biosynthetic Process
RNA Splicing
Catalytic Step 2 Spliceosome
Positive Regulation Of DNA-templated Transcription
Nucleic Acid Binding
Cellular Response To Stress
MRNA Binding
Negative Regulation Of DNA-templated Transcription
Response To Stress
Negative Regulation Of RNA Biosynthetic Process
DNA Damage Response
DNA Metabolic Process
Chromatin Remodeling
Protein-containing Complex
Spliceosomal Complex
Cell Death
Apoptotic Process
Programmed Cell Death
MAP Kinase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
MAPK Cascade
Regulation Of Cell Cycle
Ubiquitin-protein Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Cytosol
Intracellular Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Kinase Activity
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Structural Constituent Of Cytoskeleton
Regulation Of Programmed Cell Death
Response To Cytokine
Response To Peptide
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Inflammatory Response
Acetylcholine Receptor Activator Activity
Cytoplasm
Response To Light Stimulus
Positive Regulation Of Post-translational Protein Modification
Glial Cell Development
Protein Serine Kinase Activity
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Nucleotide Binding
P38MAPK Cascade
Protein Modification By Small Protein Conjugation
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Transport
Protein Serine/threonine Kinase Activity
Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Growth
Regulation Of Synapse Organization
Response To Radiation
DNA Damage Response
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Modification Process
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