USP7 and MYD88

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		USP7	MYD88
Description		ubiquitin specific peptidase 7	MYD88 innate immune signal transduction adaptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body PML Body Protein-containing Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	Signaling Receptor Binding Toll Binding Death Receptor Binding Cytokine Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity TIR Domain Binding ATP-dependent Histone Chaperone Activity
	Biological Process	Autophagosome Assembly DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Alkylation Repair Proteolysis DNA Damage Response Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi	Response To Molecule Of Fungal Origin Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Organization Chromatin Remodeling Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Microglia Differentiation Response To Amine Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Neurogenesis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-33-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Skin Development Innate Immune Response Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Neutrophil-mediated Killing Of Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		349 interacting genes: ABCB1 ABRAXAS2 ACACB ACD ACLY ADAR ADARB1 AHNAK AKIRIN1 ALB ANKS1A ANXA1 ANXA9 ARHGEF17 ARMC5 ARNT2 ASPM ATXN1 AXIN1 BACH1 BCLAF1 BCOR BEND5 BRPF1 BSN CAMSAP1 CAV1 CBR1 CBX8 CCAR1 CCDC141 CCP110 CDC42BPA CDC5L CDR2L CENPE CEP250 CGNL1 CLSPN CLTC COBLL1 CREB3L3 CRY1 CSNK2A1 CTDP1 CTTN DAXX DBN1 DCD DCTPP1 DDX17 DDX21 DDX24 DDX3X DDX5 DDX50 DDX54 DDX60 DHX15 DHX30 DHX40 DHX9 DLST DMD DNAH5 DNAJA3 DNAJC16 DNHD1 DNMT3A DSP DST DUSP2 DYRK1A ECT2 EEA1 EEF1B2 EEF1D EEF1G EFCAB5 EFTUD2 ERCC6 ETS2 EWSR1 EXOSC10 FAM120C FAM186A FANCD2 FAT2 FAT3 FBXO38 FER1L6 FLG2 FMR1 FOXM1 FOXN2 FXR1 GATA1 GIGYF2 GMPS GNL3 GOLGB1 GON4L GRM1 GRWD1 GTF2I GTPBP4 H2AC20 H2BC26 H2BC3 H3C1 HECW1 HERC1 HERPUD1 HMOX1 HNRNPC HNRNPL HNRNPM HNRNPR HRNR HSPA9 HTRA2 IFNAR1 IGF2BP1 IGF2BP3 IGHG1 IKZF1 ILF3 IPCEF1 KDR KHDRBS1 KIAA1549L KIF13A KLF12 KLHL5 KLHL8 KMT2D KRI1 LAMA1 LEPR LIMA1 LINC02582 LINGO2 LPIN3 LRBA LTF LTV1 LUC7L3 MACF1 MAGEE1 MAL MARCHF7 MAST2 MATR3 MCMBP MDC1 MDM2 MDM4 MDN1 MEX3B MINK1 MLF2 MPRIP MTREX MYBBP1A MYC MYD88 MYH13 MYO1B MYO5A MYO7B NAT10 NEB NECAB2 NEDD4L NGEF NKRF NLRP11 NOM1 NOP2 NSD1 NUMA1 OGDH OTOF OTUD4 OVCH1 PABPC1 PARP1 PBRM1 PC PCARE PCGF2 PCLAF PDE3A PEG3 PELP1 PEPD PES1 PHLDB2 PICK1 PIP PKM PLA2G2A PLCH1 PLEC PLEKHO1 PLK1 PNN PNPLA4 POLI POP1 PPARG PPFIA1 PPIP5K1 PPL PPP1R12A PRDM16 PRPF19 PRPF40A PRPF8 PSIP1 PTEN PWP1 RAD18 RAD50 RADIL RAF1 RAI14 RALY RARA RB1 RBBP4 RBCK1 RBM15 RBM39 RCC2 RELA RFC1 RFFL RGPD8 RNF168 RNF220 RPL7A RPLP0 RPS3 RPS4X RPS6 RSL1D1 RSPH1 SALL1 SAMHD1 SAP130 SAP30BP SCML2 SDK2 SENP1 SERBP1 SF3B1 SF3B2 SF3B3 SHOC2 SIRT5 SLC15A1 SLC38A6 SLC4A5 SLIT2 SMAD3 SMARCA4 SMARCA5 SMARCC1 SMARCC2 SNCA SNRNP200 SNRNP70 SNX25 SOX9 SP4 SRPK1 SRRM2 SRSF4 STAU1 SUMO2 SUPT16H SYCP1 SYNE1 SYT14 SYVN1 TANK TBCB TERT TEX15 TFIP11 THOC2 THRAP3 TMPO TNPO3 TOP2A TOP2B TP53 TPM4 TPR TPX2 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO TSC22D2 TTN U2AF2 UBA52 UBAP2 UBC UBE2D3 UBE2E1 UBE2S UBN1 UBTF UHRF1 UMPS USP21 USP28 UTP14C UTY VARS1 VCP VIM VIRMA VPS13B VPS35 WWP2 XPC XRN2 YY1 ZC3HAV1 ZFR ZGRF1 ZMYM1 ZMYND8 ZNF335 ZNF423 ZNF76	44 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF152 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35
Entrez ID		7874	4615
HPRD ID		03950	03703
Ensembl ID		ENSG00000187555	ENSG00000172936
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 A0A494C0J8 Q99836
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6M1K 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2 7VIJ 7XHH 7XHK 7XPY 8D4Z 9DEK 9DEL 9DEM 9DEN 9DEO 9DEP 9FIO 9FIP 9FIQ 9FIR 9FIS 9FIT 9FIU 9FIV 9IJU 9IML	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N 7BEQ 7BER 7L6W 8S78 8W8M
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process MRNA Processing MRNA Metabolic Process Chromatin Organization RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Cellular Response To Stress MRNA Binding Negative Regulation Of DNA-templated Transcription Response To Stress Negative Regulation Of RNA Biosynthetic Process DNA Damage Response DNA Metabolic Process Chromatin Remodeling Protein-containing Complex Spliceosomal Complex	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Defense Response To Other Organism Positive Regulation Of Immune Response Defense Response Positive Regulation Of Gene Expression Regulation Of Cytokine Production Response To Other Organism Defense Response To Symbiont Response To External Biotic Stimulus Positive Regulation Of Immune System Process Immune System Process Immune Response Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Regulation Of Interferon-beta Production Inflammatory Response Positive Regulation Of Interleukin-8 Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Interferon-beta Production Cell Surface Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-alpha Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-8 Production Interleukin-1-mediated Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?