USP7 and IKZF1

Number of citations of the paper that reports this interaction (PubMedID 35414773)
46

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		USP7	IKZF1
Description		ubiquitin specific peptidase 7	IKAROS family zinc finger 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body PML Body Protein-containing Complex	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Alkylation Repair Proteolysis DNA Damage Response Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 29296818) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 23512250 25310577 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29296818 29632299) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) hemolysis of donated blood (osmotic) ( 34014839) High density lipoprotein cholesterol levels ( 29403010 33339817) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 19862010 27863252 28017375 28453575 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 19838195 23273568 26502338 26663301 27399966 28714469) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010 33339817) Type 1 diabetes ( 25751624)
Interacting Genes		349 interacting genes: ABCB1 ABRAXAS2 ACACB ACD ACLY ADAR ADARB1 AHNAK AKIRIN1 ALB ANKS1A ANXA1 ANXA9 ARHGEF17 ARMC5 ARNT2 ASPM ATXN1 AXIN1 BACH1 BCLAF1 BCOR BEND5 BRPF1 BSN CAMSAP1 CAV1 CBR1 CBX8 CCAR1 CCDC141 CCP110 CDC42BPA CDC5L CDR2L CENPE CEP250 CGNL1 CLSPN CLTC COBLL1 CREB3L3 CRY1 CSNK2A1 CTDP1 CTTN DAXX DBN1 DCD DCTPP1 DDX17 DDX21 DDX24 DDX3X DDX5 DDX50 DDX54 DDX60 DHX15 DHX30 DHX40 DHX9 DLST DMD DNAH5 DNAJA3 DNAJC16 DNHD1 DNMT3A DSP DST DUSP2 DYRK1A ECT2 EEA1 EEF1B2 EEF1D EEF1G EFCAB5 EFTUD2 ERCC6 ETS2 EWSR1 EXOSC10 FAM120C FAM186A FANCD2 FAT2 FAT3 FBXO38 FER1L6 FLG2 FMR1 FOXM1 FOXN2 FXR1 GATA1 GIGYF2 GMPS GNL3 GOLGB1 GON4L GRM1 GRWD1 GTF2I GTPBP4 H2AC20 H2BC26 H2BC3 H3C1 HECW1 HERC1 HERPUD1 HMOX1 HNRNPC HNRNPL HNRNPM HNRNPR HRNR HSPA9 HTRA2 IFNAR1 IGF2BP1 IGF2BP3 IGHG1 IKZF1 ILF3 IPCEF1 KDR KHDRBS1 KIAA1549L KIF13A KLF12 KLHL5 KLHL8 KMT2D KRI1 LAMA1 LEPR LIMA1 LINC02582 LINGO2 LPIN3 LRBA LTF LTV1 LUC7L3 MACF1 MAGEE1 MAL MARCHF7 MAST2 MATR3 MCMBP MDC1 MDM2 MDM4 MDN1 MEX3B MINK1 MLF2 MPRIP MTREX MYBBP1A MYC MYD88 MYH13 MYO1B MYO5A MYO7B NAT10 NEB NECAB2 NEDD4L NGEF NKRF NLRP11 NOM1 NOP2 NSD1 NUMA1 OGDH OTOF OTUD4 OVCH1 PABPC1 PARP1 PBRM1 PC PCARE PCGF2 PCLAF PDE3A PEG3 PELP1 PEPD PES1 PHLDB2 PICK1 PIP PKM PLA2G2A PLCH1 PLEC PLEKHO1 PLK1 PNN PNPLA4 POLI POP1 PPARG PPFIA1 PPIP5K1 PPL PPP1R12A PRDM16 PRPF19 PRPF40A PRPF8 PSIP1 PTEN PWP1 RAD18 RAD50 RADIL RAF1 RAI14 RALY RARA RB1 RBBP4 RBCK1 RBM15 RBM39 RCC2 RELA RFC1 RFFL RGPD8 RNF168 RNF220 RPL7A RPLP0 RPS3 RPS4X RPS6 RSL1D1 RSPH1 SALL1 SAMHD1 SAP130 SAP30BP SCML2 SDK2 SENP1 SERBP1 SF3B1 SF3B2 SF3B3 SHOC2 SIRT5 SLC15A1 SLC38A6 SLC4A5 SLIT2 SMAD3 SMARCA4 SMARCA5 SMARCC1 SMARCC2 SNCA SNRNP200 SNRNP70 SNX25 SOX9 SP4 SRPK1 SRRM2 SRSF4 STAU1 SUMO2 SUPT16H SYCP1 SYNE1 SYT14 SYVN1 TANK TBCB TERT TEX15 TFIP11 THOC2 THRAP3 TMPO TNPO3 TOP2A TOP2B TP53 TPM4 TPR TPX2 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO TSC22D2 TTN U2AF2 UBA52 UBAP2 UBC UBE2D3 UBE2E1 UBE2S UBN1 UBTF UHRF1 UMPS USP21 USP28 UTP14C UTY VARS1 VCP VIM VIRMA VPS13B VPS35 WWP2 XPC XRN2 YY1 ZC3HAV1 ZFR ZGRF1 ZMYM1 ZMYND8 ZNF335 ZNF423 ZNF76	107 interacting genes: AEN AIRIM ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 ATOSB BARD1 BYSL C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I USP7 ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587
Entrez ID		7874	10320
HPRD ID		03950	04318
Ensembl ID		ENSG00000187555	ENSG00000185811
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	A0A2R8Y4D3 A0A2R8YFR0 A0A8V8TNQ0 C9JTB0 Q13422 R9R4D9
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6M1K 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2 7VIJ 7XHH 7XHK 7XPY 8D4Z 9DEK 9DEL 9DEM 9DEN 9DEO 9DEP 9FIO 9FIP 9FIQ 9FIR 9FIS 9FIT 9FIU 9FIV 9IJU 9IML	6H0F 8D7Z 8D80 8RQC 8TNP 8TNQ 8TNR
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process MRNA Processing MRNA Metabolic Process Chromatin Organization RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Cellular Response To Stress MRNA Binding Negative Regulation Of DNA-templated Transcription Response To Stress Negative Regulation Of RNA Biosynthetic Process DNA Damage Response DNA Metabolic Process Chromatin Remodeling Protein-containing Complex Spliceosomal Complex	Nucleoplasm Nucleus DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein Binding Sin3-type Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Androgen Receptor Signaling Pathway Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process PML Body Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Cell Fate Specification Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Metabolic Process Nuclear Speck U2-type Precatalytic Spliceosome Chromatin Organization RNA Splicing Negative Regulation Of Metabolic Process Protein K6-linked Ubiquitination DNA Repair
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