USP7 and AXIN1

Number of citations of the paper that reports this interaction (PubMedID 31519875)
60

Data Source:
BioGRID (pull down, enzymatic study)

		USP7	AXIN1
Description		ubiquitin specific peptidase 7	axin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body PML Body Protein-containing Complex	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Cell Periphery Wnt Signalosome
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	P53 Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding Protein Serine/threonine Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Autophagosome Assembly DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Alkylation Repair Proteolysis DNA Damage Response Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi	Protein Polyubiquitination In Utero Embryonic Development Nucleocytoplasmic Transport Apoptotic Process Sensory Perception Of Sound Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Wnt Signaling Pathway Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Post-anal Tail Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of JNK Cascade Axial Mesoderm Development Axial Mesoderm Formation Cell Development Negative Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Head Development Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs			1,4-Dithiothreitol
Diseases			Caudal duplication anomaly Hepatocellular carcinoma
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)
Interacting Genes		349 interacting genes: ABCB1 ABRAXAS2 ACACB ACD ACLY ADAR ADARB1 AHNAK AKIRIN1 ALB ANKS1A ANXA1 ANXA9 ARHGEF17 ARMC5 ARNT2 ASPM ATXN1 AXIN1 BACH1 BCLAF1 BCOR BEND5 BRPF1 BSN CAMSAP1 CAV1 CBR1 CBX8 CCAR1 CCDC141 CCP110 CDC42BPA CDC5L CDR2L CENPE CEP250 CGNL1 CLSPN CLTC COBLL1 CREB3L3 CRY1 CSNK2A1 CTDP1 CTTN DAXX DBN1 DCD DCTPP1 DDX17 DDX21 DDX24 DDX3X DDX5 DDX50 DDX54 DDX60 DHX15 DHX30 DHX40 DHX9 DLST DMD DNAH5 DNAJA3 DNAJC16 DNHD1 DNMT3A DSP DST DUSP2 DYRK1A ECT2 EEA1 EEF1B2 EEF1D EEF1G EFCAB5 EFTUD2 ERCC6 ETS2 EWSR1 EXOSC10 FAM120C FAM186A FANCD2 FAT2 FAT3 FBXO38 FER1L6 FLG2 FMR1 FOXM1 FOXN2 FXR1 GATA1 GIGYF2 GMPS GNL3 GOLGB1 GON4L GRM1 GRWD1 GTF2I GTPBP4 H2AC20 H2BC26 H2BC3 H3C1 HECW1 HERC1 HERPUD1 HMOX1 HNRNPC HNRNPL HNRNPM HNRNPR HRNR HSPA9 HTRA2 IFNAR1 IGF2BP1 IGF2BP3 IGHG1 IKZF1 ILF3 IPCEF1 KDR KHDRBS1 KIAA1549L KIF13A KLF12 KLHL5 KLHL8 KMT2D KRI1 LAMA1 LEPR LIMA1 LINC02582 LINGO2 LPIN3 LRBA LTF LTV1 LUC7L3 MACF1 MAGEE1 MAL MARCHF7 MAST2 MATR3 MCMBP MDC1 MDM2 MDM4 MDN1 MEX3B MINK1 MLF2 MPRIP MTREX MYBBP1A MYC MYD88 MYH13 MYO1B MYO5A MYO7B NAT10 NEB NECAB2 NEDD4L NGEF NKRF NLRP11 NOM1 NOP2 NSD1 NUMA1 OGDH OTOF OTUD4 OVCH1 PABPC1 PARP1 PBRM1 PC PCARE PCGF2 PCLAF PDE3A PEG3 PELP1 PEPD PES1 PHLDB2 PICK1 PIP PKM PLA2G2A PLCH1 PLEC PLEKHO1 PLK1 PNN PNPLA4 POLI POP1 PPARG PPFIA1 PPIP5K1 PPL PPP1R12A PRDM16 PRPF19 PRPF40A PRPF8 PSIP1 PTEN PWP1 RAD18 RAD50 RADIL RAF1 RAI14 RALY RARA RB1 RBBP4 RBCK1 RBM15 RBM39 RCC2 RELA RFC1 RFFL RGPD8 RNF168 RNF220 RPL7A RPLP0 RPS3 RPS4X RPS6 RSL1D1 RSPH1 SALL1 SAMHD1 SAP130 SAP30BP SCML2 SDK2 SENP1 SERBP1 SF3B1 SF3B2 SF3B3 SHOC2 SIRT5 SLC15A1 SLC38A6 SLC4A5 SLIT2 SMAD3 SMARCA4 SMARCA5 SMARCC1 SMARCC2 SNCA SNRNP200 SNRNP70 SNX25 SOX9 SP4 SRPK1 SRRM2 SRSF4 STAU1 SUMO2 SUPT16H SYCP1 SYNE1 SYT14 SYVN1 TANK TBCB TERT TEX15 TFIP11 THOC2 THRAP3 TMPO TNPO3 TOP2A TOP2B TP53 TPM4 TPR TPX2 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO TSC22D2 TTN U2AF2 UBA52 UBAP2 UBC UBE2D3 UBE2E1 UBE2S UBN1 UBTF UHRF1 UMPS USP21 USP28 UTP14C UTY VARS1 VCP VIM VIRMA VPS13B VPS35 WWP2 XPC XRN2 YY1 ZC3HAV1 ZFR ZGRF1 ZMYM1 ZMYND8 ZNF335 ZNF423 ZNF76	91 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 FXR1 FXR2 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KAT5 KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RCHY1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSC1 TSGA10 UCHL5 USP10 USP7 UTP14A WSB1 ZBTB26 ZFYVE19
Entrez ID		7874	8312
HPRD ID		03950	04819
Ensembl ID		ENSG00000187555	ENSG00000103126
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6M1K 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2 7VIJ 7XHH 7XHK 7XPY 8D4Z 9DEK 9DEL 9DEM 9DEN 9DEO 9DEP 9FIO 9FIP 9FIQ 9FIR 9FIS 9FIT 9FIU 9FIV 9IJU 9IML	1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK 7SXF 7SXG 7SXH 7SXJ 7Y1P 8RU3 8RU4 8VMG
Enriched GO Terms of Interacting Partners?		Nucleus RNA Binding Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process MRNA Processing MRNA Metabolic Process Chromatin Organization RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Cellular Response To Stress MRNA Binding Negative Regulation Of DNA-templated Transcription Response To Stress Negative Regulation Of RNA Biosynthetic Process DNA Damage Response DNA Metabolic Process Chromatin Remodeling Protein-containing Complex Spliceosomal Complex	Wnt Signaling Pathway Cytoplasm Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Wnt Signalosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-catenin Destruction Complex Signal Transduction Beta-catenin Binding PML Body Positive Regulation Of Biosynthetic Process
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