USP7 and RNF220

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		USP7	RNF220
Gene Name		ubiquitin specific peptidase 7 (herpes virus-associated)	ring finger protein 220
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol PML Body	Cytoplasm
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Transcription-coupled Nucleotide-excision Repair Multicellular Organismal Development Maintenance Of DNA Methylation Viral Process Histone Deubiquitination Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process	Protein Ubiquitination Protein Autoubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		85 interactors: ACD ARNT2 ATXN1 BCOR BEND5 BMI1 CBX8 CHEK1 CLSPN CREB3L3 DAXX DNAJA3 DNMT1 DNMT3A EWSR1 EZH2 FAM175B FOXN2 HECW1 HERPUD1 HIST3H2BB HTRA2 KAT5 KLHL8 MAGEE1 MAL MARCH7 MCMBP MDM2 MDM4 MYD88 NECAB2 PCGF2 PEG3 PEPD PHLDB2 PICK1 PJA1 PLA2G2A PLEKHO1 PPARG PPL RADIL RARA RB1 RBCK1 RELA RFFL RING1 RNF2 RNF220 SMAD3 SUMO1 SUZ12 SYVN1 TANK TBCB TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM27 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBC UBE2E1 UBE2S UHRF2 USP15 USP21 USP28 WWP2 XPC ZEB1 ZMYND8 ZNF423	4 interactors: GOPC SIN3B UBE2D3 USP7
Entrez ID		7874	55182
HPRD ID		03950	13336
Ensembl ID		ENSG00000187555	ENSG00000187147
Uniprot IDs		B7Z815 Q6U8A4 Q93009	B4DLZ9 Q5VTB9
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Metabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Process Modification-dependent Protein Catabolic Process Chromosome Organization Chromatin Organization Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Transcription, DNA-templated Cellular Macromolecule Catabolic Process Apoptotic Process RNA Biosynthetic Process Programmed Cell Death Chromatin Modification Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Histone Ubiquitination Cell Death	Cytoplasmic Sequestering Of CFTR Protein Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Golgi To Plasma Membrane Protein Transport Maintenance Of DNA Methylation Regulation Of Golgi To Plasma Membrane Protein Transport Histone Modification Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Apical Protein Localization Proteolysis Involved In Cellular Protein Catabolic Process Histone Deubiquitination Cellular Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane DNA Repair Chromatin Modification Protein K11-linked Ubiquitination Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cytoplasmic Sequestering Of Protein Asymmetric Protein Localization Spermatid Nucleus Differentiation Chromatin Organization Golgi To Plasma Membrane Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein K48-linked Ubiquitination Transcription-coupled Nucleotide-excision Repair Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Negative Regulation Of Type I Interferon Production Transcription From RNA Polymerase II Promoter Organelle Organization Regulation Of Protein Localization To Plasma Membrane Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Metabolic Process Chromosome Organization TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Histone Deacetylation MyD88-independent Toll-like Receptor Signaling Pathway DNA Metabolic Process Toll-like Receptor 3 Signaling Pathway Protein Deacetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Difference) ?		accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Intersection) ?