TSC2 and MRPL21

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		TSC2	MRPL21
Name		TSC complex subunit 2	mitochondrial ribosomal protein L21
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Translation Mitochondrial Translation
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Diseases		Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease	None
GWAS		Major depressive disorder ( 29317602 ) Obesity-related traits ( 23251661 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	3 interacting genes: ERCC6 TSC2 UBC
Entrez ID		7249	219927
HPRD ID		01850	14747
Ensembl ID		ENSG00000103197	ENSG00000197345
Uniprot IDs		A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2	B4DXI4 Q7Z2W9
PDB IDs		7DL2 9CE3	3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8PK0 8QSJ 8QU1 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3
GO Terms Enriched among Interactors		Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity	B-WICH Complex Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Protection Transcription Elongation By RNA Polymerase I Single Strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Response To Superoxide Pyrimidine Dimer Repair Response To Oxygen Radical Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of Mitophagy TSC1-TSC2 Complex Anoikis Positive Regulation Of Transcription By RNA Polymerase III Transcription Elongation Factor Complex Protein Localization To Organelle Response To UV-B ATP-dependent Chromatin Remodeler Activity RNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity Protein Tyrosine Kinase Activator Activity Positive Regulation Of Peptidyl-serine Phosphorylation Chromatin-protein Adaptor Activity Protein Ubiquitination Protein Tag Activity