TSC2 and YWHAB

Number of citations of the paper that reports this interaction (PMID 12364343)
20

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TSC2	YWHAB
Gene Name		tuberous sclerosis 2	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Caveola Membrane Dendrite Growth Cone TSC1-TSC2 Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Transcriptional Repressor Complex Cytoplasmic Vesicle Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Protein Homodimerization Activity Protein Heterodimerization Activity 14-3-3 Protein Binding	Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Protein Complex Binding Histone Deacetylase Binding Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Acute-phase Response Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Heart Development Protein Localization Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Cell Projection Organization Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Ras GTPase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Protein Transport Into Plasma Membrane Raft Innate Immune Response Negative Regulation Of Cell Size Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Protein Homooligomerization Protein Heterooligomerization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling	MAPK Cascade Activation Of MAPKK Activity Protein Targeting Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Negative Regulation Of Protein Dephosphorylation Hippo Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Protein Heterooligomerization Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulation of Rheb GTPase activity by AMPK mTOR signalling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Inhibition of TSC complex formation by PKB PIP3 activates AKT signaling IRS-mediated signalling mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Energy dependent regulation of mTOR by LKB1-AMPK Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Inhibition of TSC complex formation by PKB Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade	Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF Regulation of mRNA stability by proteins that bind AU-rich elements DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR Programmed Cell Death NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Signaling by Hippo RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: AKT1 AKT2 AKT3 CALM1 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PPP2CA PRKAA1 PTK2 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SPERT TBC1D7 TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	137 interactors: ABL1 ADAM22 AKAP13 ALS2 APP ATP5A1 BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EPB41 EPB41L1 EPB41L3 EXO1 FER FRMD6 GAPVD1 GEM HDAC5 HES1 HIST1H3A HSP90AB1 HSPA1A HSPA1B HSPA5 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLLT4 MLXIP MPRIP MST1R OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRPK2 SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		7249	7529
HPRD ID		01850	03184
Ensembl ID		ENSG00000103197	ENSG00000166913
Uniprot IDs		P49815	P31946
PDB IDs			2BQ0 2C23 4DNK
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Transport Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Mitochondrion Organization Response To Growth Factor Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Response To Organic Substance Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Apoptotic Process Signal Transduction Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Mitochondrion Organization Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Cellular Response To Insulin Stimulus Response To Stimulus Cellular Response To Peptide Hormone Stimulus	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cell Communication Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Response To Organic Substance Cellular Response To Stimulus Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Signaling Protein Phosphorylation Cell Cycle Response To Growth Factor Response To Stimulus Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Process Neurotrophin Signaling Pathway Innate Immune Response Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Growth Factor Stimulus Phosphorylation Cellular Localization Cellular Response To Insulin Stimulus Anatomical Structure Development Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Immune System Process Regulation Of Metabolic Process
Tagcloud ?		c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Difference) ?		c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Intersection) ?