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TSC2 and PTK2
Number of citations of the paper that reports this interaction (PubMedID
17043358
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology, pull down)
HPRD
(in vivo)
TSC2
PTK2
Description
TSC complex subunit 2
protein tyrosine kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Synapse
Perinuclear Region Of Cytoplasm
Stress Fiber
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cilium
Cell Cortex
Membrane
Ciliary Basal Body
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Nucleotide Binding
Actin Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
ATP Binding
JUN Kinase Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
Molecular Function Activator Activity
Biological Process
Neural Tube Closure
Cytoplasmic Translation
Protein Import Into Nucleus
Endocytosis
Heart Development
Intracellular Protein Localization
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
TORC1 Signaling
Anoikis
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Mitophagy
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Angiogenesis
Placenta Development
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Cell-matrix Adhesion
Heart Morphogenesis
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Endothelial Cell Migration
Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Cell-cell Adhesion
Establishment Of Cell Polarity
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Detection Of Muscle Stretch
Netrin-activated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Regulation Of Cell Differentiation
Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Cell Motility
Regulation Of Multicellular Organismal Process
Regulation Of Cytoskeleton Organization
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Wound Healing
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
Positive Regulation Of Macrophage Proliferation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Anoikis
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Signal regulatory protein family interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
FCGR3A-mediated phagocytosis
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Endostatin
7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
Fostamatinib
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
Apolipoprotein B levels (
32203549
)
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29892015
30061737
)
Deep white matter hyperintensities (
32517579
)
Diastolic blood pressure (
30224653
)
LDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin (
27863252
)
Mood instability (
31168069
)
Multisite chronic pain (
33830993
)
Nickel levels (
26025379
)
PR interval (
32439900
)
Red cell distribution width (
32888494
)
Response to interferon beta therapy (
21502966
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
61 interacting genes:
ACTN2
AKT1
AKT2
AKT3
ANKRD35
BTG3
CALM1
CBY2
CCND1
CDKN1B
EEF1A1
ESR1
FBXL6
FBXW5
GAPDH
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
MKRN1
MRPL21
NEK1
PAM
PHLDB1
PICK1
PIN1
PLK2
PPP1CA
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPL4
RPS6KA1
RPSA
SEPTIN4
SERPINI1
SFN
SLC13A3
SMAD2
SMAD3
SSC4D
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
USPL1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
117 interacting genes:
ACTN1
APP
ARHGAP26
ASAP1
ATG12
BBS10
BCAR1
BIN1
BMX
CCR5
CD47
CD79B
CIB1
CRK
CSK
CSPG4
CXCR4
DCC
DDX39A
DEF6
DLGAP3
DNM2
DOK4
EEF1G
EFS
EGFR
EPHA2
EPHB2
EPS8L2
ERBB2
ERBB3
EZR
FBP1
FGR
FLT1
FLT4
FYN
GIT1
GRB2
GRB7
GSK3B
GZMB
HES1
HSPA13
IGHM
INSR
IRS1
ITGAV
ITGB1
ITGB2
ITGB3
ITGB4
ITGB5
JAK2
KCNB1
KCNMA1
LCK
LPXN
LYN
MAPK8IP3
MDM2
MICAL1
MISP
MORC3
NACAD
NASP
NCK1
NCK2
NEDD8
NEDD9
NEO1
PDGFRB
PIAS1
PIK3R1
PIK3R3
PKD1
PLCG1
PPP1CB
PTK2B
PTPN11
PTPN12
PTPRH
PXN
RAC1
RB1CC1
RET
RIPK1
ROCK1
SAE1
SELE
SH2D1A
SH2D1B
SHC1
SKP2
SOCS1
SOCS2
SOCS3
SORBS1
SRC
SRPK1
STAT1
SYK
TGFB1I1
TLN1
TNFRSF1A
TNS1
TNS3
TP53
TRIM15
TRIO
TRIP6
TSC2
VCL
WEE2-AS1
YES1
ZFYVE21
ZNF331
Entrez ID
7249
5747
HPRD ID
01850
02859
Ensembl ID
ENSG00000103197
ENSG00000169398
Uniprot IDs
A0A2R8Y6C9
A0A2R8YDZ2
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D2U8
X5D7Q2
A0A8Q3WLM4
B4DWJ1
E5RFW9
E7ESA6
Q05397
Q59GM6
Q59GN8
PDB IDs
7DL2
9CE3
1K04
1K05
1MP8
1OW6
1OW7
1OW8
2ETM
2IJM
3B71
3BZ3
3PXK
3S9O
4EBV
4EBW
4GU6
4GU9
4I4E
4I4F
4K8A
4K9Y
4KAB
4KAO
4NY0
4Q9S
6I8Z
6LES
6PW8
6YOJ
6YQ1
6YR9
6YT6
6YVS
6YVY
6YXV
7PI4
7W7Z
7W8B
7W8I
7W9U
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Protein Modification Process
Protein Metabolic Process
Phosphoserine Residue Binding
Regulation Of TOR Signaling
Cytosol
TOR Signaling
Negative Regulation Of TOR Signaling
Protein Kinase Binding
Cytoplasm
TORC1 Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Biological Quality
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Regulation Of Signal Transduction
Protein Domain Specific Binding
Macromolecule Metabolic Process
Cellular Response To Stress
Protein Sequestering Activity
Ciliary Basal Body
Identical Protein Binding
Insulin Receptor Signaling Pathway
Signal Transduction
Protein Kinase Activity
Cellular Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Kinase Activity
Protein Phosphorylation
Protein Serine Kinase Activity
Regulation Of Synaptic Plasticity
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Organelle Organization
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Negative Regulation Of Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Cell Communication
Nucleus
Regulation Of Immune Response
Regulation Of Protein Metabolic Process
Protein Serine/threonine Kinase Activity
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Focal Adhesion
Signal Transduction
Cell Migration
Cell Motility
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Protein Tyrosine Kinase Activity
Anchoring Junction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Cell Adhesion
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Plasma Membrane
Regulation Of Apoptotic Process
Response To Growth Factor
Positive Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Migration
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Immune System Process
Regulation Of Cell Motility
Regulation Of Cellular Component Organization
Ruffle Membrane
Integrin-mediated Signaling Pathway
Regulation Of Locomotion
Regulation Of Immune System Process
Protein Kinase Activity
Intracellular Signal Transduction
Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Developmental Process
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Protein Phosphorylation
Receptor Complex
Ephrin Receptor Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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