TSC2 and TK1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TSC2	TK1
Gene Name		tuberous sclerosis 2	thymidine kinase 1, soluble
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Caveola Membrane Dendrite Growth Cone TSC1-TSC2 Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Protein Homodimerization Activity Protein Heterodimerization Activity 14-3-3 Protein Binding	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Acute-phase Response Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Heart Development Protein Localization Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Cell Projection Organization Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Ras GTPase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Protein Transport Into Plasma Membrane Raft Innate Immune Response Negative Regulation Of Cell Size Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Protein Homooligomerization Protein Heterooligomerization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulation of Rheb GTPase activity by AMPK mTOR signalling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Inhibition of TSC complex formation by PKB PIP3 activates AKT signaling IRS-mediated signalling mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Energy dependent regulation of mTOR by LKB1-AMPK Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Inhibition of TSC complex formation by PKB Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade	Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs			Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: AKT1 AKT2 AKT3 CALM1 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PPP2CA PRKAA1 PTK2 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SPERT TBC1D7 TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		7249	7083
HPRD ID		01850	01771
Ensembl ID		ENSG00000103197	ENSG00000167900
Uniprot IDs		P49815	P04183
PDB IDs			1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Transport Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Mitochondrion Organization Response To Growth Factor Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Response To Organic Substance Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Apoptotic Process Signal Transduction Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Mitochondrion Organization Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Cellular Response To Insulin Stimulus Response To Stimulus Cellular Response To Peptide Hormone Stimulus	Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus
Tagcloud ?		c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Difference) ?		c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Intersection) ?