TSC2 and GSK3B

Number of citations of the paper that reports this interaction (PMID 12511557)
20

Data Source:
HPRD (in vivo)

		TSC2	GSK3B
Gene Name		tuberous sclerosis 2	glycogen synthase kinase 3 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Caveola Membrane Dendrite Growth Cone TSC1-TSC2 Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Growth Cone Ribonucleoprotein Complex Beta-catenin Destruction Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Protein Homodimerization Activity Protein Heterodimerization Activity 14-3-3 Protein Binding	RNA Polymerase II Transcription Factor Binding P53 Binding Protein Serine/threonine Kinase Activity Integrin Binding Protein Binding ATP Binding Beta-catenin Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Ionotropic Glutamate Receptor Binding Tau Protein Binding Tau-protein Kinase Activity NF-kappaB Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Acute-phase Response Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Heart Development Protein Localization Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Cell Projection Organization Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Ras GTPase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Protein Transport Into Plasma Membrane Raft Innate Immune Response Negative Regulation Of Cell Size Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Protein Homooligomerization Protein Heterooligomerization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling	Re-entry Into Mitotic Cell Cycle Epithelial To Mesenchymal Transition Positive Regulation Of Cell-matrix Adhesion Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Protein Export From Nucleus ER Overload Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Myoblast Fusion Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Response To Lithium Ion Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Maturation Cell Migration Peptidyl-serine Phosphorylation Hippocampus Development Establishment Of Cell Polarity Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rac GTPase Activity Regulation Of Microtubule-based Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Protein Localization To Microtubule Intracellular Signal Transduction Cellular Response To Interleukin-3 Fc-epsilon Receptor Signaling Pathway Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Canonical Wnt Signaling Pathway Superior Temporal Gyrus Development Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Heat Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Stem Cell Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulation of Rheb GTPase activity by AMPK mTOR signalling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Inhibition of TSC complex formation by PKB PIP3 activates AKT signaling IRS-mediated signalling mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Energy dependent regulation of mTOR by LKB1-AMPK Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Inhibition of TSC complex formation by PKB Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade	Signaling by the B Cell Receptor (BCR) Hedgehog 'off' state Signaling by FGFR in disease misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Signaling by PDGF DAP12 interactions GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer CRMPs in Sema3A signaling Adaptive Immune System Axon guidance PIP3 activates AKT signaling APC truncation mutants have impaired AXIN binding APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated PI3K events in ERBB2 signaling Downstream signaling of activated FGFR XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System Signalling by NGF Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer Regulation of HSF1-mediated heat shock response Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR TCF dependent signaling in response to WNT Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs			Lithium 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione I-5 N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea Staurosporine Indirubin-3\'-Monoxime Adenosine-5\'-Diphosphate (3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: AKT1 AKT2 AKT3 CALM1 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PPP2CA PRKAA1 PTK2 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SPERT TBC1D7 TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	206 interactors: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATPIF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCL3 BEX1 BICD1 BICD2 BRIX1 BTRC BZW2 C14orf1 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPZ CENPB CHD3 CIITA CLEC3B CREB1 CREM CSAD CST6 CTNNB1 CTNND1 DBI DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DHX34 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DUSP9 DYNC1I1 E2F1 EEF1A1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 EYA1 FAM193B FAM83D FBN3 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GAPDH GBP2 GIPC1 GJB5 GNB2 GPR39 GYS1 HDAC4 HNRNPD HSP90AA1 HSPA4 IGHM IGSF21 IKBKG ILK IQCG JUN KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LRP6 LUC7L2 MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MGEA5 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYOCD NAT9 NBR1 NCOA3 NFE2L1 NFE2L2 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGT PDE4D PFKFB4 PHLPP1 PIK3R1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PSEN1 PTK2 PTN PTPN1 PXN QARS RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD1 SMAD3 SNAI1 SNCA SNCAIP SPTBN4 SREBF1 SYNE4 TAZ TLE1 TMEM132A TMEM44 TONSL TP53 TPPP TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 WSB1 XPNPEP1 YBX1 YBX3 ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746
Entrez ID		7249	2932
HPRD ID		01850	05418
Ensembl ID		ENSG00000103197	ENSG00000082701
Uniprot IDs		P49815	P49841 Q6FI27
PDB IDs			1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3PUP 3Q3B 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Transport Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Mitochondrion Organization Response To Growth Factor Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Response To Organic Substance Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Apoptotic Process Signal Transduction Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Mitochondrion Organization Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Cellular Response To Insulin Stimulus Response To Stimulus Cellular Response To Peptide Hormone Stimulus	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Gene Expression Response To Stress Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Signal Transduction Apoptotic Process Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Protein Metabolic Process Cell Death Death Programmed Cell Death Regulation Of Cell Differentiation Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Gene Expression Multicellular Organismal Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Negative Regulation Of Transcription, DNA-templated Cell Differentiation Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous	200mg clamp coagulation confirmation dm downregulated encountered f3 gskbeta3 hg hi hour hyperglycemia hyperinsulinemia ingenuity monocyte monocytes pik3c3 platelet platelets proinflammatory prothrombotic ptpn1 ptpn11 qrt stxbp4 tf tfpi thrombin
Tagcloud (Difference) ?		c3 calpactine carcinogenesis clones complement designated dominantly eker erc example excellent fos fra gap3 germline gives gtpase hereditary homologous homologue inherited insertion mendelian predisposition representational rise subtracted tuberine tuberous	200mg clamp coagulation confirmation dm downregulated encountered f3 gskbeta3 hg hi hour hyperglycemia hyperinsulinemia ingenuity monocyte monocytes pik3c3 platelet platelets proinflammatory prothrombotic ptpn1 ptpn11 qrt stxbp4 tf tfpi thrombin
Tagcloud (Intersection) ?