TSC2 and ANKRD35

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		TSC2	ANKRD35
Name		TSC complex subunit 2	ankyrin repeat domain 35
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm	None
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding	Actin Binding
	Biological Process	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	None
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs	None
Diseases		Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease	None
GWAS		Major depressive disorder ( 29317602 ) Obesity-related traits ( 23251661 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	7 interacting genes: CACNA1C RBCK1 SHANK3 SRPK2 TSC1 TSC2 VIM
Entrez ID		7249	148741
HPRD ID		01850	08050
Ensembl ID		ENSG00000103197	ENSG00000198483
Uniprot IDs		A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2	B4DFX6 F6XZD3 Q8N283
PDB IDs		7DL2 9CE3	Not available
GO Terms Enriched among Interactors		Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity	TSC1-TSC2 Complex Postsynaptic Density Hsp90 Protein Binding Negative Regulation Of Macroautophagy Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Actin Filament-based Process Intracellular Signal Transduction Memory T Cell Differentiation Positive Regulation Of TOR Signaling Negative Regulation Of Autophagy Negative Regulation Of TORC1 Signaling Tube Closure Positive Regulation Of TORC1 Signaling Regulation Of Cell Size Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling TORC1 Signaling Associative Learning Neural Tube Closure Scaffold Protein Binding Guanylate Kinase-associated Protein Clustering Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Tube Formation Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Signal Transduction Nuclear Speck Organization Regulation Of TOR Signaling Adult Behavior LUBAC Complex Synaptic Receptor Adaptor Activity Membrane Depolarization During AV Node Cell Action Potential Immune System Development ATPase Inhibitor Activity Learning Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Signal Transduction Cellular Response To Starvation Keratin Filament Binding Regulation Of Macroautophagy Protein Linear Polyubiquitination Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Heart Development Regulation Of Ventricular Cardiac Muscle Cell Action Potential