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CUL1 and TRIM21
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(biochemical, affinity chromatography technology, biochemical, pull down)
CUL1
TRIM21
Description
cullin 1
tripartite motif containing 21
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
P-body
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Cytosol
Cytoplasmic Stress Granule
SCF Ubiquitin Ligase Complex
Cytoplasmic Vesicle
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Lysosome Organization
Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Oxidative Stress
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Antiviral Innate Immune Response
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Autophagosome Assembly
Protein Polyubiquitination
Protein Monoubiquitination
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Proteasomal Protein Catabolic Process
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Binding
Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Stress Granule Assembly
Response To Type II Interferon
Stress Granule Disassembly
Protein K27-linked Ubiquitination
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Cell Cycle
Negative Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Viral Entry Into Host Cell
Protein Autoubiquitination
Cellular Response To Chemical Stress
Pyroptotic Inflammatory Response
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Protein Deubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
Interferon gamma signaling
KEAP1-NFE2L2 pathway
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Lung cancer (
28604730
)
Malaria (
31844061
)
Interacting Genes
62 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CEBPA
CENPE
CENPW
CFLAR
CFTR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
DVL2
E2F1
EIF4ENIF1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
FBXW8
GHR
GPS1
HIPK2
HOOK1
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
86 interacting genes:
AGO4
AIFM2
ALOX15B
APC
ATG5
CASP8AP2
CBX4
CDC34
CDKN1A
CLSPN
CUL1
CWC25
DAXX
DCP2
DLGAP1-AS2
DMAP1
DZIP3
EHHADH
ELAVL1
EXOC8
FADD
FBXW11
FHOD1
G3BP1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GRAP
HLA-DRB1
IGFN1
IGHG1
IGHV4-31
IKBKB
IRF5
IRF8
LNX1
LPP
MAP1LC3A
MAP1LC3B
MAP1LC3C
MNAT1
NAT8
NIF3L1
PFKP
PPP1CA
RAB11FIP1
RAB11FIP5
RNF111
RO60
SAMHD1
SETD7
SIRT5
SKP2
STK3
TBK1
TCP11L1
TNS4
TP53
TRIM27
TRIM3
TRIM39
TRIM5
TRIM8
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G2
UBE2I
UBE2L3
UBE2N
UBE2V1
UBE2W
USP15
USP2
USP4
VPS9D1
WEE2-AS1
XAF1
YJU2
YWHAZ
ZBTB16
Entrez ID
8454
6737
HPRD ID
04389
00170
Ensembl ID
ENSG00000055130
ENSG00000132109
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
P19474
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8CAF
8CDJ
8CDK
8OR0
8OR2
8OR3
8OR4
8UA6
8UBT
8UBU
8VVY
9JKB
9KBD
2IWG
5JPX
5OLM
6FGA
6S53
7BBD
8A58
8Y58
8Y59
8Y5B
9QBA
Enriched GO Terms of Interacting Partners
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Protein Modification By Small Protein Conjugation
SCF Ubiquitin Ligase Complex
Post-translational Protein Modification
Protein Modification Process
Protein Metabolic Process
Protein Neddylation
Macromolecule Metabolic Process
Cytosol
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Nucleus
Nucleoplasm
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Deneddylation
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Protein K48-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Intracellular Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
NEDD8 Ligase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Neddylation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Protein Monoubiquitination
Ubiquitin-like Ligase-substrate Adaptor Activity
Cullin Family Protein Binding
Positive Regulation Of Signal Transduction
Protein Destabilization
Intracellular Signal Transduction
Regulation Of Protein Modification Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Protein Modification Process
Protein Ubiquitination
Cellular Response To Nitrogen Starvation
Cytosol
Ubiquitin Protein Ligase Binding
Cellular Response To Nutrient Levels
Catabolic Process
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Phosphatidylethanolamine Binding
Protein Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Response To Nutrient Levels
Mitophagy
Response To Stress
Cellular Response To Stress
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Defense Response To Virus
Cytoplasm
Cellular Response To Starvation
Autophagosome Organization
Macromolecule Metabolic Process
Protein K48-linked Ubiquitination
Autophagy Of Mitochondrion
Regulation Of Protein Ubiquitination
Nucleus
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Virus
Proteolysis
Response To Starvation
Vacuole Organization
Positive Regulation Of Protein Polyubiquitination
Autophagosome Assembly
TORC1 Signaling
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Post-translational Protein Modification
Defense Response To Other Organism
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Metabolic Process
Transferase Activity
Positive Regulation Of Protein Ubiquitination
PML Body
Protein K63-linked Ubiquitination
Macroautophagy
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Tagcloud (Intersection)
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