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TRIM21 and APC
Number of citations of the paper that reports this interaction (PubMedID
29045831
)
47
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
TRIM21
APC
Description
tripartite motif containing 21
APC regulator of Wnt signaling pathway
Image
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Cytosol
Cytoplasmic Stress Granule
SCF Ubiquitin Ligase Complex
Cytoplasmic Vesicle
Ribonucleoprotein Complex
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Leading Edge Membrane
Ruffle Membrane
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Plasma Membrane Bounded Cell Projection
Wnt Signalosome
Molecular Function
DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Autophagosome Assembly
Protein Polyubiquitination
Protein Monoubiquitination
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Proteasomal Protein Catabolic Process
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Binding
Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Stress Granule Assembly
Response To Type II Interferon
Stress Granule Disassembly
Protein K27-linked Ubiquitination
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Cell Cycle
Negative Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Viral Entry Into Host Cell
Protein Autoubiquitination
Cellular Response To Chemical Stress
Pyroptotic Inflammatory Response
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Protein Deubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Mitotic Cytokinesis
Cell Fate Specification
Heart Valve Development
Endocardial Cushion Morphogenesis
DNA Damage Response
Negative Regulation Of Microtubule Depolymerization
Mitotic Spindle Assembly Checkpoint Signaling
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Wnt Signaling Pathway
Cell Migration
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Microtubule-based Movement
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Localization To Centrosome
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
Interferon gamma signaling
KEAP1-NFE2L2 pathway
Antigen processing: Ubiquitination & Proteasome degradation
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Drugs
Diseases
Cancer of the anal canal
Familial adenomatous polyposis
Gastric cancer
Esophageal cancer
Gallbladder cancer
GWAS
Lung cancer (
28604730
)
Malaria (
31844061
)
Age at first sexual intercourse (
34211149
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Appendicular lean mass (
33097823
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Daytime nap (
33568662
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
86 interacting genes:
AGO4
AIFM2
ALOX15B
APC
ATG5
CASP8AP2
CBX4
CDC34
CDKN1A
CLSPN
CUL1
CWC25
DAXX
DCP2
DLGAP1-AS2
DMAP1
DZIP3
EHHADH
ELAVL1
EXOC8
FADD
FBXW11
FHOD1
G3BP1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GRAP
HLA-DRB1
IGFN1
IGHG1
IGHV4-31
IKBKB
IRF5
IRF8
LNX1
LPP
MAP1LC3A
MAP1LC3B
MAP1LC3C
MNAT1
NAT8
NIF3L1
PFKP
PPP1CA
RAB11FIP1
RAB11FIP5
RNF111
RO60
SAMHD1
SETD7
SIRT5
SKP2
STK3
TBK1
TCP11L1
TNS4
TP53
TRIM27
TRIM3
TRIM39
TRIM5
TRIM8
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G2
UBE2I
UBE2L3
UBE2N
UBE2V1
UBE2W
USP15
USP2
USP4
VPS9D1
WEE2-AS1
XAF1
YJU2
YWHAZ
ZBTB16
135 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
ATOSA
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG1
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PKNOX1
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
ZNF106
ZNF510
Entrez ID
6737
324
HPRD ID
00170
01439
Ensembl ID
ENSG00000132109
ENSG00000134982
Uniprot IDs
P19474
P25054
R4GMU6
PDB IDs
2IWG
5JPX
5OLM
6FGA
6S53
7BBD
8A58
8Y58
8Y59
8Y5B
9QBA
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
7F6M
7F7O
7XTY
8GSJ
8X2Q
Enriched GO Terms of Interacting Partners
?
Post-translational Protein Modification
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Protein Modification Process
Protein Ubiquitination
Cellular Response To Nitrogen Starvation
Cytosol
Ubiquitin Protein Ligase Binding
Cellular Response To Nutrient Levels
Catabolic Process
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Phosphatidylethanolamine Binding
Protein Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Response To Nutrient Levels
Mitophagy
Response To Stress
Cellular Response To Stress
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Defense Response To Virus
Cytoplasm
Cellular Response To Starvation
Autophagosome Organization
Macromolecule Metabolic Process
Protein K48-linked Ubiquitination
Autophagy Of Mitochondrion
Regulation Of Protein Ubiquitination
Nucleus
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Virus
Proteolysis
Response To Starvation
Vacuole Organization
Positive Regulation Of Protein Polyubiquitination
Autophagosome Assembly
TORC1 Signaling
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Post-translational Protein Modification
Defense Response To Other Organism
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Metabolic Process
Transferase Activity
Positive Regulation Of Protein Ubiquitination
PML Body
Protein K63-linked Ubiquitination
Macroautophagy
Organelle Organization
Structural Constituent Of Nuclear Pore
Cytoskeleton Organization
Supramolecular Fiber Organization
Cytosol
MRNA Transport
Nuclear Export
Nuclear Pore
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Beta-catenin Destruction Complex
Nuclear Transport
Nucleocytoplasmic Transport
RNA Transport
Nuclear Membrane
RNA Export From Nucleus
Cellular Localization
Cytoskeleton
Intracellular Protein Localization
Regulation Of Nucleocytoplasmic Transport
Intracellular Transport
Nucleobase-containing Compound Transport
Nuclear Localization Sequence Binding
Nuclear Envelope
Establishment Of Localization In Cell
Cadherin Binding
Regulation Of Protein Localization
Actin Filament Binding
Glutamatergic Synapse
Regulation Of Cellular Localization
Protein Export From Nucleus
Hemidesmosome
Intracellular Protein Transport
Actin Binding
Nucleus
Protein Transport
Cellular Component Assembly
Positive Regulation Of Nucleocytoplasmic Transport
Establishment Of Protein Localization
Cytoplasm
Regulation Of Cytoskeleton Organization
Canonical Wnt Signaling Pathway
Regulation Of Intracellular Transport
Structural Molecule Activity
Intermediate Filament Organization
Nuclear Pore Nuclear Basket
Regulation Of Intracellular Protein Transport
Nuclear Pore Organization
Microtubule
Regulation Of Centromeric Sister Chromatid Cohesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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