TRIM21 and IRF8

Number of citations of the paper that reports this interaction (PubMedID 17579016)
0

Data Source:
BioGRID (enzymatic study)

		TRIM21	IRF8
Description		tripartite motif containing 21	interferon regulatory factor 8
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Response To Bacterium Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Dendritic Cell Differentiation Defense Response To Other Organism
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)	Aspartate aminotransferase levels ( 33547301) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Behcet's disease ( 33393726) Chronic lymphocytic leukemia ( 21131588 24292274 28165464 23770605 26956414) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Major depressive disorder x sex interaction ( 34099189) Monocyte count ( 27863252 32888494 23314186 28193307 29403010) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244 19525953 24076602 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 24390342 23143596 22446963 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe insulin-deficient type 2 diabetes ( 34737425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26663301 26502338 33272962 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)
Interacting Genes		86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16	12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17
Entrez ID		6737	3394
HPRD ID		00170	03336
Ensembl ID		ENSG00000132109	ENSG00000140968
Uniprot IDs		P19474	H3BRT4 Q02556
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy	Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Canonical NF-kappaB Signal Transduction NF-kappaB P50/p65 Complex DNA-templated Transcription Regulation Of Innate Immune Response Response To Virus Negative Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Non-canonical NF-kappaB Signal Transduction Follicular B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of RNA Metabolic Process Defense Response To Virus Toll-like Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Cytokine Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Defense Response Cellular Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Defense Response To Tumor Cell Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Cytokine-mediated Signaling Pathway Defense Response Antiviral Innate Immune Response Actinin Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Positive Regulation Of Type I Interferon Production Sequence-specific DNA Binding Immune System Process Positive Regulation Of Defense Response Cellular Response To Lipid
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