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CUL1 and SKP1
Number of citations of the paper that reports this interaction (PubMedID
17290223
)
44
Data Source:
HPRD
(in vitro, in vivo)
CUL1
SKP1
Description
cullin 1
S-phase kinase associated protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
Molecular Function Activator Activity
Ubiquitin Ligase Complex Scaffold Activity
F-box Domain Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Lysosome Organization
Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Oxidative Stress
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Antiviral Innate Immune Response
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Protein Polyubiquitination
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Location In Nucleus
Axon Development
Protein K48-linked Ubiquitination
Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
26502338
27399966
)
Interacting Genes
62 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CEBPA
CENPE
CENPW
CFLAR
CFTR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
DVL2
E2F1
EIF4ENIF1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
FBXW8
GHR
GPS1
HIPK2
HOOK1
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
75 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CFLAR
CKS1B
CUL1
CUL7
DDX19B
FBH1
FBXL2
FBXL20
FBXL3
FBXL4
FBXL5
FBXL8
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
Entrez ID
8454
6500
HPRD ID
04389
03255
Ensembl ID
ENSG00000055130
ENSG00000113558
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
P63208
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8CAF
8CDJ
8CDK
8OR0
8OR2
8OR3
8OR4
8UA6
8UBT
8UBU
8VVY
9JKB
9KBD
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
7B5L
7B5M
7B5R
7T1Y
7T1Z
7Z8B
7Z8T
7Z8V
7ZBW
7ZBZ
8BYA
8BYL
8CDJ
8CDK
8OR0
8OR3
8OR4
8S7D
8S7E
8UA6
8UBT
8UBU
9CB3
9JKB
9KBD
9KBF
Enriched GO Terms of Interacting Partners
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Protein Modification By Small Protein Conjugation
SCF Ubiquitin Ligase Complex
Post-translational Protein Modification
Protein Modification Process
Protein Metabolic Process
Protein Neddylation
Macromolecule Metabolic Process
Cytosol
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Nucleus
Nucleoplasm
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Deneddylation
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Protein K48-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Intracellular Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
NEDD8 Ligase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Neddylation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Protein Monoubiquitination
Ubiquitin-like Ligase-substrate Adaptor Activity
Cullin Family Protein Binding
Positive Regulation Of Signal Transduction
Protein Destabilization
Intracellular Signal Transduction
Regulation Of Protein Modification Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
SCF Ubiquitin Ligase Complex
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Protein Catabolic Process
Protein Catabolic Process
Post-translational Protein Modification
Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Modification Process
Ubiquitin Ligase Complex
Ubiquitin-like Ligase-substrate Adaptor Activity
Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Catabolic Process
Regulation Of Cell Cycle
Ubiquitin Protein Ligase Binding
Cytosol
Ubiquitin-protein Transferase Activity
Cullin-RING Ubiquitin Ligase Complex
Cytoplasm
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Glycoprotein Catabolic Process
Regulation Of DNA Metabolic Process
Cul7-RING Ubiquitin Ligase Complex
Positive Regulation Of DNA Metabolic Process
Protein K48-linked Ubiquitination
Ubiquitin Protein Ligase Activity
Regulation Of Cell Cycle Process
Regulation Of Protein Stability
Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Protein Binding
Regulation Of Protein Ubiquitination
Cellular Response To Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Metabolic Process
TORC1 Signaling
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