TRIM21 and PFKP

Number of citations of the paper that reports this interaction (PubMedID 29038421)
36

Data Source:
BioGRID (enzymatic study)

		TRIM21	PFKP
Description		tripartite motif containing 21	phosphofructokinase, platelet
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Extracellular Exosome
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Fructose-6-phosphate Binding
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Canonical Glycolysis Cellular Response To Leukemia Inhibitory Factor
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation	Glycolysis
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body size at age 10 ( 32376654) Disc degeneration (lumbar) ( 22993228) HDL cholesterol levels in HIV infection ( 33109212) Hippocampal volume in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Scalp hair shape ( 26926045) Subclinical trait of interstitial lung disease (percentage of high attenuation areas on CT scan) ( 28521775)
Interacting Genes		86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16	15 interacting genes: ACD AGO2 AKT1 DYNLL1 EGFR KAT5 LINC00632 NUTF2 POT1 SUMO2 TERF1 TINF2 TRIM21 VHL WNK1
Entrez ID		6737	5214
HPRD ID		00170	01384
Ensembl ID		ENSG00000132109	ENSG00000067057
Uniprot IDs		P19474	A0A7I2V3Z0 A0A8V8TMY4 B1APP6 Q01813
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2 7TFF
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Regulation Of DNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process RNA-templated DNA Biosynthetic Process Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Positive Regulation Of Metabolic Process Positive Regulation Of Organelle Organization Telomere Organization Positive Regulation Of Cell Cycle Establishment Of Protein Localization To Organelle Regulation Of Establishment Of Protein Localization To Telomere Organelle Organization Activation-induced Cell Death Of T Cells Regulation Of Autophagy Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Primary Metabolic Process Negative Regulation Of Catabolic Process Chromosome, Telomeric Region Nitric-oxide Synthase Regulator Activity Chromosome Telomeric D-loop Disassembly DNA Metabolic Process Positive Regulation Of Cellular Component Organization
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