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TRIM21 and RNF111
Number of citations of the paper that reports this interaction (PMID
22493164
)
2
Data Source:
BioGRID
(two hybrid)
TRIM21
RNF111
Gene Name
tripartite motif containing 21
ring finger protein 111
Image
Gene Ontology Annotations
Cellular Component
Cytoplasmic MRNA Processing Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein Complex
Molecular Function
DNA Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Identical Protein Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Polymer Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
Protein Monoubiquitination
Cell Cycle
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Innate Immune Response
Positive Regulation Of Cell Cycle
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Autoubiquitination
Interferon-gamma-mediated Signaling Pathway
Protein Trimerization
Negative Regulation Of Protein Deubiquitination
Negative Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Gene Expression
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Interferon gamma signaling
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of innate immune responses to cytosolic DNA
Cytosolic sensors of pathogen-associated DNA
STING mediated induction of host immune responses
Interferon Signaling
Cytokine Signaling in Immune system
Class I MHC mediated antigen processing & presentation
Innate Immune System
Adaptive Immune System
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Class I MHC mediated antigen processing & presentation
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Asperger disorder (
21182207
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
37 interactors:
APC
CASP8AP2
CDC34
CUL1
DAXX
DCP2
DZIP3
FADD
FBXW11
GRAP
HLA-DRB1
IGHG1
IGHV4-31
IKBKB
IRF8
MNAT1
NIF3L1
RBCK1
RNF111
SKP2
TRIM27
TRIM39
TRIM5
TRIM8
TROVE2
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2H
UBE2I
UBE2L3
USP15
USP2
USP4
YWHAZ
39 interactors:
ACTN3
ANAPC11
AXIN1
CREB1
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP5-9
LCE4A
LRSAM1
MARCH7
MVP
PHF7
PML
SMAD3
SMAD6
SMAD7
SMURF2
SUMO2
TRAF5
TRIM21
TRIM8
TSG101
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2Q2
UBE2V1
UBE2W
Entrez ID
6737
54778
HPRD ID
00170
09318
Ensembl ID
ENSG00000132109
ENSG00000157450
Uniprot IDs
P19474
Q6ZNA4
PDB IDs
2IWG
2KIZ
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Catabolic Process
Cellular Protein Modification Process
Proteolysis
Regulation Of Protein Ubiquitination
Protein Metabolic Process
Regulation Of Proteolysis
Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Mitotic Cell Cycle Process
Protein K48-linked Ubiquitination
Regulation Of Protein Metabolic Process
Cell Cycle
Cell Cycle Phase Transition
Regulation Of Protein Catabolic Process
Mitotic Cell Cycle
Innate Immune Response
Cell Cycle Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Stimulus
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cell Communication
Activation Of Innate Immune Response
Regulation Of Signaling
Positive Regulation Of Ubiquitin-protein Transferase Activity
Cellular Metabolic Process
Cell Surface Receptor Signaling Pathway
Mitotic Cell Cycle Phase Transition
Regulation Of Signal Transduction
Positive Regulation Of Ligase Activity
Response To Stimulus
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Polyubiquitination
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein K11-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Catabolic Process
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Gene Expression
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Protein Monoubiquitination
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Catabolic Process
Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud
?
2ms
3ms
440ms
addressable
adjusting
albia
antibodies
bead
confounders
corrected
ekg
erythematosus
immunoassay
lupus
multicenter
prolongation
prolonged
qt
qtc
reasons
repolarization
resting
ro
ro52
ro60
separately
ss
ssc
univariate
Tagcloud (Difference)
?
2ms
3ms
440ms
addressable
adjusting
albia
antibodies
bead
confounders
corrected
ekg
erythematosus
immunoassay
lupus
multicenter
prolongation
prolonged
qt
qtc
reasons
repolarization
resting
ro
ro52
ro60
separately
ss
ssc
univariate
Tagcloud (Intersection)
?