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CUL1 and E2F1
Number of citations of the paper that reports this interaction (PubMedID
10559858
)
0
Data Source:
HPRD
(in vitro, in vivo)
CUL1
E2F1
Description
cullin 1
E2F transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Nuclear Chromosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Lysosome Organization
Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Oxidative Stress
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Antiviral Innate Immune Response
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
DNA Damage Checkpoint Signaling
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Forebrain Development
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Regulation Of Cell Cycle
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
62 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CEBPA
CENPE
CENPW
CFLAR
CFTR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
DVL2
E2F1
EIF4ENIF1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
FBXW8
GHR
GPS1
HIPK2
HOOK1
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
83 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CCNF
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB1
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
SZRD1P1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
8454
1869
HPRD ID
04389
01806
Ensembl ID
ENSG00000055130
ENSG00000101412
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
Q01094
Q9BSD8
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8CAF
8CDJ
8CDK
8OR0
8OR2
8OR3
8OR4
8UA6
8UBT
8UBU
8VVY
9JKB
9KBD
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
9CB3
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
SCF Ubiquitin Ligase Complex
Post-translational Protein Modification
Protein Modification Process
Protein Metabolic Process
Protein Neddylation
Macromolecule Metabolic Process
Cytosol
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Nucleus
Nucleoplasm
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Deneddylation
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Protein K48-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Intracellular Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
NEDD8 Ligase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Neddylation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Protein Monoubiquitination
Ubiquitin-like Ligase-substrate Adaptor Activity
Cullin Family Protein Binding
Positive Regulation Of Signal Transduction
Protein Destabilization
Intracellular Signal Transduction
Regulation Of Protein Modification Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Chromatin Organization
DNA Damage Response
Chromatin Remodeling
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Repair
G1/S Transition Of Mitotic Cell Cycle
DNA Metabolic Process
Cell Cycle G1/S Phase Transition
Chromatin
Cellular Response To Stress
Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Protein Localization To Site Of Double-strand Break
Positive Regulation Of DNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Programmed Cell Death
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