CUL1 and CDCA3

Number of citations of the paper that reports this interaction (PMID 12679038)
38

Data Source:
HPRD (in vitro, in vivo)

		CUL1	CDCA3
Gene Name		cullin 1	cell division cycle associated 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Cellular_component Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Molecular_function
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Monoubiquitination Cell Cycle Arrest Notch Signaling Pathway Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Viral Process Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway	Mitotic Nuclear Division Biological_process Protein Ubiquitination Cell Division
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Cyclin E associated events during G1/S transition Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex G1/S Transition AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex Signaling by NOTCH phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase S Phase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding G2/M Transition APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer G1 Phase Cytokine Signaling in Immune system Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nuclear signaling by ERBB4 Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Protein-Protein Interactions		55 interactors: ARIH1 BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CHEK1 CHUK CKS1B COMMD1 COPS2 COPS5 COPS6 COPS7A COPS8 DCUN1D4 E2F1 FBXO18 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GLMN GPS1 HIPK2 NEDD8 NFKBIA NFKBIB NFKBIE NLK NR1D2 PARK2 PPP1CA PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBE2E3 UBE2F UBE2M ZC3HC1	9 interactors: APP BCL11A CTDSP1 CTDSP2 CUL1 SKP1 TRAF1 TRAF2 WEE1
Entrez ID		8454	83461
HPRD ID		04389	09670
Ensembl ID		ENSG00000055130	ENSG00000111665
Uniprot IDs		B3KTW0 Q13616	B2R749 F5GX58 Q99618
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Ubiquitination Cellular Protein Metabolic Process Protein Deneddylation Protein Metabolic Process Cullin Deneddylation Cell Cycle Mitotic Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Protein Polyubiquitination Cellular Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Viral Process Cellular Response To Stimulus Response To Growth Factor Response To Organic Substance Cell Communication Protein Modification By Small Protein Removal Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Protein Ubiquitination Signal Transduction	Cellular Protein Modification Process Positive Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Neuron Differentiation Protein Modification By Small Protein Conjugation Regulation Of Mitotic Cell Cycle Phase Transition Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Monoubiquitination Positive Regulation Of Catalytic Activity Negative Regulation Of Neurogenesis Negative Regulation Of Cell Development Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Protein Modification Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Apoptotic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Programmed Cell Death Positive Regulation Of Ligase Activity Regulation Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Cycle Process Synaptic Growth At Neuromuscular Junction Regulation Of Catalytic Activity Regulation Of Phosphorylation Regulation Of Neuron Differentiation
Tagcloud ?		autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34	agilent aifm1 antiproliferative biologically cables2 ccnk cdc25b cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2
Tagcloud (Difference) ?		autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34	agilent aifm1 antiproliferative biologically cables2 ccnk cdc25b cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2
Tagcloud (Intersection) ?