TRIM21 and CDC34

Number of citations of the paper that reports this interaction (PubMedID 16472766)
0

Data Source:
BioGRID (pull down)

		TRIM21	CDC34
Description		tripartite motif containing 21	cell division cycle 34, ubiquitin conjugating enzyme
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation	Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16	60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1
Entrez ID		6737	997
HPRD ID		00170	00306
Ensembl ID		ENSG00000132109	ENSG00000099804
Uniprot IDs		P19474	P49427
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA	2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction
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