CUL1 and CENPE

Number of citations of the paper that reports this interaction (PubMedID 19779646)
0

Data Source:
BioGRID (two hybrid)

		CUL1	CENPE
Description		cullin 1	centromere protein E
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Spindle Midzone Mitotic Spindle Mitotic Spindle Midzone
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Kinetochore Binding
	Biological Process	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Lysosome Organization Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Oxidative Stress TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling	Mitotic Cell Cycle Nuclear Division Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs			GSK-923295
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)	Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)
Interacting Genes		62 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CEBPA CENPE CENPW CFLAR CFTR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 DVL2 E2F1 EIF4ENIF1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 FBXW8 GHR GPS1 HIPK2 HOOK1 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1	13 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC USP7
Entrez ID		8454	1062
HPRD ID		04389	00316
Ensembl ID		ENSG00000055130	ENSG00000138778
Uniprot IDs		A0A090N7U0 B3KTW0 Q13616	Q02224
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CAF 8CDJ 8CDK 8OR0 8OR2 8OR3 8OR4 8UA6 8UBT 8UBU 8VVY 9JKB 9KBD	1T5C 5JVP 6M4I 8HFH 8OWI 8WHL
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification Process Protein Metabolic Process Protein Neddylation Macromolecule Metabolic Process Cytosol Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Nucleus Nucleoplasm Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Deneddylation Macromolecule Catabolic Process NEDD8 Transferase Activity Protein K48-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Polyubiquitination Cytoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intracellular Signal Transduction Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Protein Monoubiquitination Ubiquitin-like Ligase-substrate Adaptor Activity Cullin Family Protein Binding Positive Regulation Of Signal Transduction Protein Destabilization Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Chromosome, Centromeric Region Kinetochore Regulation Of Mitotic Sister Chromatid Separation TORC1 Signaling Ubiquitin Ligase Complex Scaffold Activity Nucleus Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization Cytosol TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Autophagosome Assembly Regulation Of TORC1 Signaling Autophagosome Organization Regulation Of Sister Chromatid Segregation Kinetochore Organization Negative Regulation Of Autophagy Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Apoptotic Process Chromosome Regulation Of Chromosome Segregation Organelle Assembly Regulation Of Nuclear Division Regulation Of TOR Signaling Organelle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Vacuole Organization Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Spindle Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Nucleoplasm SCF Ubiquitin Ligase Complex Protein Ubiquitination Negative Regulation Of Cell Cycle Process Negative Regulation Of TORC1 Signaling Regulation Of Embryonic Cell Shape Ubiquitin Protein Ligase Binding Intracellular Signal Transduction Regulation Of Organelle Organization
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