CUL1 and PARK2

Number of citations of the paper that reports this interaction (PMID 12628165)
82

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CUL1	PARK2
Gene Name		cullin 1	parkin RBR E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm LUBAC Complex Lewy Body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	G-protein Coupled Receptor Binding Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity SH3 Domain Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Monoubiquitination Cell Cycle Arrest Notch Signaling Pathway Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Viral Process Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Mitochondrial Fission Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Startle Response Transcription, DNA-templated Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Regulation Of Autophagy Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Regulation Of Dopamine Secretion Protein Ubiquitination Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Norepinephrine Metabolic Process Dopamine Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Protein K27-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Zinc Ion Homeostasis Negative Regulation Of Cell Death Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Cyclin E associated events during G1/S transition Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex G1/S Transition AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex Signaling by NOTCH phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase S Phase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding G2/M Transition APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer G1 Phase Cytokine Signaling in Immune system Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nuclear signaling by ERBB4 Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Aging ( 22773346) Disc degeneration (lumbar) ( 22993228) Metabolite levels ( 19043545) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		55 interactors: ARIH1 BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CHEK1 CHUK CKS1B COMMD1 COPS2 COPS5 COPS6 COPS7A COPS8 DCUN1D4 E2F1 FBXO18 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GLMN GPS1 HIPK2 NEDD8 NFKBIA NFKBIB NFKBIE NLK NR1D2 PARK2 PPP1CA PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBE2E3 UBE2F UBE2M ZC3HC1	77 interactors: AIMP2 ARR3 ARRB2 ATXN3 BAG5 CASK CASP1 CASP8 CDK5 CHPF CRX CSNK1A1 CUL1 DLG1 DLX2 DNM1L DYT10 EPS15 FAM46C FBP1 FBXO7 FBXW7 GPR37 GRIN2B HEXDC IKBKG MEOX1 MEOX2 MFN1 NDUFA4L2 PAFAH1B2 PDCD2 PICK1 PRKACA PSMA1 PSMA7 PSMC5 PSMD4 RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 SEPT4 SEPT5 SIM2 SNCA SNCAIP STUB1 SYT11 TCF4 TOMM40 TOMM70A TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2J1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2V1 UCHL1 YWHAH ZNF746
Entrez ID		8454	5071
HPRD ID		04389	03967
Ensembl ID		ENSG00000055130	ENSG00000185345
Uniprot IDs		B3KTW0 Q13616	O60260 Q5VVX4
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52	1IYF 2JMO 4BM9 4I1F 4I1H
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Ubiquitination Cellular Protein Metabolic Process Protein Deneddylation Protein Metabolic Process Cullin Deneddylation Cell Cycle Mitotic Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Protein Polyubiquitination Cellular Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Viral Process Cellular Response To Stimulus Response To Growth Factor Response To Organic Substance Cell Communication Protein Modification By Small Protein Removal Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Protein Ubiquitination Signal Transduction	Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Death Death Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud ?		autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34	ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?