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TRIM21 and IGHV4-31
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
TRIM21
IGHV4-31
Gene Name
tripartite motif containing 21
immunoglobulin heavy variable 4-31
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasmic MRNA Processing Body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Ribonucleoprotein Complex
Molecular Function
DNA Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Identical Protein Binding
Biological Process
Protein Polyubiquitination
Protein Monoubiquitination
Cell Cycle
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Innate Immune Response
Positive Regulation Of Cell Cycle
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Autoubiquitination
Interferon-gamma-mediated Signaling Pathway
Protein Trimerization
Negative Regulation Of Protein Deubiquitination
Negative Regulation Of Viral Release From Host Cell
Pathways
Interferon gamma signaling
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of innate immune responses to cytosolic DNA
Cytosolic sensors of pathogen-associated DNA
STING mediated induction of host immune responses
Interferon Signaling
Cytokine Signaling in Immune system
Class I MHC mediated antigen processing & presentation
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
APC
CASP8AP2
CDC34
CUL1
DAXX
DCP2
DZIP3
FADD
FBXW11
GRAP
HLA-DRB1
IGHG1
IGHV4-31
IKBKB
IRF8
MNAT1
NIF3L1
RBCK1
RNF111
SKP2
TRIM27
TRIM39
TRIM5
TRIM8
TROVE2
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2H
UBE2I
UBE2L3
USP15
USP2
USP4
YWHAZ
1 interactors:
TRIM21
Entrez ID
6737
28396
HPRD ID
00170
Ensembl ID
ENSG00000132109
Uniprot IDs
P19474
PDB IDs
2IWG
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Catabolic Process
Cellular Protein Modification Process
Proteolysis
Regulation Of Protein Ubiquitination
Protein Metabolic Process
Regulation Of Proteolysis
Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Mitotic Cell Cycle Process
Protein K48-linked Ubiquitination
Regulation Of Protein Metabolic Process
Cell Cycle
Cell Cycle Phase Transition
Regulation Of Protein Catabolic Process
Mitotic Cell Cycle
Innate Immune Response
Cell Cycle Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Stimulus
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cell Communication
Activation Of Innate Immune Response
Regulation Of Signaling
Positive Regulation Of Ubiquitin-protein Transferase Activity
Cellular Metabolic Process
Cell Surface Receptor Signaling Pathway
Mitotic Cell Cycle Phase Transition
Regulation Of Signal Transduction
Positive Regulation Of Ligase Activity
Response To Stimulus
Negative Regulation Of Protein Deubiquitination
Positive Regulation Of Viral Entry Into Host Cell
Regulation Of Protein Deubiquitination
Negative Regulation Of Viral Release From Host Cell
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Transcription
Regulation Of Viral Release From Host Cell
Protein Destabilization
Protein Trimerization
Protein Monoubiquitination
Protein Autoubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Negative Regulation Of Viral Process
Positive Regulation Of Type I Interferon Production
Regulation Of Type I Interferon Production
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Protein Stability
Cellular Response To Interferon-gamma
Regulation Of Viral Process
Response To Interferon-gamma
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Cell Cycle
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Locomotion
Positive Regulation Of Cytokine Production
Tagcloud
?
2ms
3ms
440ms
addressable
adjusting
albia
antibodies
bead
confounders
corrected
ekg
erythematosus
immunoassay
lupus
multicenter
prolongation
prolonged
qt
qtc
reasons
repolarization
resting
ro
ro52
ro60
separately
ss
ssc
univariate
Tagcloud (Difference)
?
2ms
3ms
440ms
addressable
adjusting
albia
antibodies
bead
confounders
corrected
ekg
erythematosus
immunoassay
lupus
multicenter
prolongation
prolonged
qt
qtc
reasons
repolarization
resting
ro
ro52
ro60
separately
ss
ssc
univariate
Tagcloud (Intersection)
?