CUL1 and CKS1B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		CUL1	CKS1B
Description		cullin 1	CDC28 protein kinase regulatory subunit 1B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Lysosome Organization Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Oxidative Stress TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling	Regulation Of Mitotic Cell Cycle Cell Division
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1
Drugs			Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)
Interacting Genes		62 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CEBPA CENPE CENPW CFLAR CFTR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 DVL2 E2F1 EIF4ENIF1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 FBXW8 GHR GPS1 HIPK2 HOOK1 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1	57 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9
Entrez ID		8454	1163
HPRD ID		04389	00299
Ensembl ID		ENSG00000055130	ENSG00000173207
Uniprot IDs		A0A090N7U0 B3KTW0 Q13616	P61024 Q5T178
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CAF 8CDJ 8CDK 8OR0 8OR2 8OR3 8OR4 8UA6 8UBT 8UBU 8VVY 9JKB 9KBD	1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification Process Protein Metabolic Process Protein Neddylation Macromolecule Metabolic Process Cytosol Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Nucleus Nucleoplasm Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Deneddylation Macromolecule Catabolic Process NEDD8 Transferase Activity Protein K48-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Polyubiquitination Cytoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intracellular Signal Transduction Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Protein Monoubiquitination Ubiquitin-like Ligase-substrate Adaptor Activity Cullin Family Protein Binding Positive Regulation Of Signal Transduction Protein Destabilization Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity
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