TRIM21 and USP2

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		TRIM21	USP2
Gene Name		tripartite motif containing 21	ubiquitin specific peptidase 2
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Centrosome Cell Cortex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein Trimerization Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Regulation Of Proteasomal Protein Catabolic Process
Pathways		Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		37 interactors: APC CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF8 MNAT1 NIF3L1 RBCK1 RNF111 SKP2 TRIM27 TRIM39 TRIM5 TRIM8 TROVE2 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 YWHAZ	67 interactors: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC36 CCDC57 CCDC85B CCND1 CRY1 DTX3 ERBB2 GOLGA2 HOMER3 HOOK1 HOOK2 IKBKG KIFC3 KRT15 KRT40 LHX4 LNX2 LONRF1 LRSAM1 LZTS2 MAP3K2 MDM2 MNAT1 MTUS2 NDEL1 NEFL NFKB2 PCGF6 PCNA PLA2G2A PNMA1 RAD18 RBCK1 RIPK1 RNF125 RNF126 RNF144B RNF166 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBC UBE2S UBOX5 USP21 VPS52
Entrez ID		6737	9099
HPRD ID		00170	05287
Ensembl ID		ENSG00000132109	ENSG00000036672
Uniprot IDs		P19474	E9PPM2 O75604
PDB IDs		2IWG	2HD5 2IBI 3NHE 3V6C 3V6E
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Modification Process Proteolysis Regulation Of Protein Ubiquitination Protein Metabolic Process Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Mitotic Cell Cycle Innate Immune Response Cell Cycle Process Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cell Communication Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Ligase Activity Response To Stimulus	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein K63-linked Ubiquitination Protein Metabolic Process Cellular Protein Catabolic Process Defense Response Protein Complex Assembly Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stress Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Trimerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Catabolic Process Response To Cytokine Positive Regulation Of MAP Kinase Activity
Tagcloud ?		2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate	accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Difference) ?		2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate	accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Intersection) ?