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CUL1 and NFKBIE
Number of citations of the paper that reports this interaction (PubMedID
14743216
)
0
Data Source:
HPRD
(in vitro)
CUL1
NFKBIE
Description
cullin 1
NFKB inhibitor epsilon
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Fibrillar Center
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Protein Binding
Protein Sequestering Activity
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Lysosome Organization
Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Oxidative Stress
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Antiviral Innate Immune Response
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Activation of NF-kappaB in B cells
Drugs
Diseases
Hodgkin lymphoma
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Rheumatoid arthritis (
22446963
23028356
24390342
30423114
32723749
)
Interacting Genes
62 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CEBPA
CENPE
CENPW
CFLAR
CFTR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
DVL2
E2F1
EIF4ENIF1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
FBXW8
GHR
GPS1
HIPK2
HOOK1
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
15 interacting genes:
ANKHD1
C1QBP
CUL1
HDAC4
HDAC5
IL1A
JUP
KBTBD7
NCOR2
NFKB1
NFKB2
PPP6C
REL
RELA
SKP1
Entrez ID
8454
4794
HPRD ID
04389
05181
Ensembl ID
ENSG00000055130
ENSG00000146232
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
O00221
Q7LC14
Q96F31
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8CAF
8CDJ
8CDK
8OR0
8OR2
8OR3
8OR4
8UA6
8UBT
8UBU
8VVY
9JKB
9KBD
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
SCF Ubiquitin Ligase Complex
Post-translational Protein Modification
Protein Modification Process
Protein Metabolic Process
Protein Neddylation
Macromolecule Metabolic Process
Cytosol
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Nucleus
Nucleoplasm
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Deneddylation
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Protein K48-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Intracellular Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
NEDD8 Ligase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Neddylation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Protein Monoubiquitination
Ubiquitin-like Ligase-substrate Adaptor Activity
Cullin Family Protein Binding
Positive Regulation Of Signal Transduction
Protein Destabilization
Intracellular Signal Transduction
Regulation Of Protein Modification Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Non-canonical NF-kappaB Signal Transduction
Defense Response
Response To External Biotic Stimulus
NF-kappaB P50/p65 Complex
Canonical NF-kappaB Signal Transduction
Immune System Process
I-kappaB/NF-kappaB Complex
Immune Response
Innate Immune Response
NF-kappaB Complex
Histone Deacetylase Binding
Defense Response To Symbiont
Defense Response To Other Organism
Response To Lipopolysaccharide
Cytosol
Inflammatory Response
Response To Molecule Of Bacterial Origin
Cellular Response To Nicotine
Ubiquitin Ligase Complex Scaffold Activity
Cellular Response To Lipopolysaccharide
Regulation Of Interleukin-12 Production
Histone Deacetylase Activity, Hydrolytic Mechanism
Positive Regulation Of Transcription By RNA Polymerase II
Response To Stress
Cellular Response To Molecule Of Bacterial Origin
Protein Lysine Deacetylase Activity
Actinin Binding
Nucleoplasm
Tissue Remodeling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Angiotensin
Regulation Of MiRNA Metabolic Process
Cellular Response To Interleukin-6
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Myotube Differentiation
Response To Other Organism
Histone Deacetylase Activity
Transcription Cis-regulatory Region Binding
Response To Interleukin-6
Regulation Of Transcription By RNA Polymerase II
Response To Lipid
Protein K48-linked Ubiquitination
Nucleus
Regulation Of Signal Transduction
Positive Regulation Of Epithelial Cell Apoptotic Process
Regulation Of Protein Sumoylation
DNA-binding Transcription Activator Activity
Response To Angiotensin
Response To Cytokine
Response To Muscle Stretch
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Tagcloud (Intersection)
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