TRIM21 and SAMHD1

Number of citations of the paper that reports this interaction (PubMedID 31797533)
77

Data Source:
BioGRID (pull down, fluorescent resonance energy transfer)

		TRIM21	SAMHD1
Description		tripartite motif containing 21	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Nucleus Nucleoplasm Chromosome Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Catalytic Activity RNA Nuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Hydrolase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding Metal Ion Binding Deoxynucleoside Triphosphate Hydrolase Activity
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Double-strand Break Repair Via Homologous Recombination Immune System Process DGTP Catabolic Process DNA Replication DNA Repair Immune Response DNA Damage Response Deoxyribonucleotide Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Innate Immune Response Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway DNA Strand Resection Involved In Replication Fork Processing
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation	Nucleotide catabolism Interferon alpha/beta signaling
Drugs
Diseases			Aicardi-Goutieres Syndrome (AGS)
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)	Caffeine consumption from coffee or tea ( 33287642) Height ( 28552196)
Interacting Genes		86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16	15 interacting genes: ACTB APP ARAP3 CDK1 CHUK DYSF FAM13B FBXO25 FBXO7 IKBKB NONO SUMO2 TIRAP TRIM21 USP7
Entrez ID		6737	25939
HPRD ID		00170	08418
Ensembl ID		ENSG00000132109	ENSG00000101347
Uniprot IDs		P19474	A0A2R8YCS7 Q59H15 Q9Y3Z3
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA	2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM 7A5Y 7LTT 7LU5 7S2Y 7UJN 8D94 8D9J 8GB1 8GB2 8QXJ 8QXK 8QXL 8QXM 8QXN 8QXO 8TDV 8TDW 9EC2
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy	Regulation Of Innate Immune Response IkappaB Kinase Activity Post-translational Protein Modification Regulation Of Cellular Component Organization Innate Immune Response CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Transferrin Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response IkappaB Kinase Complex Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Positive Regulation Of Defense Response Defense Response To Other Organism Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Circadian Rhythm Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Immune System Process Regulation Of Type I Interferon Production Protein Ubiquitination Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Immune System Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Response To Copper Ion Regulation Of Proteolysis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Immune Response
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