TRIM21 and TRIM39

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM21	TRIM39
Gene Name		tripartite motif containing 21	tripartite motif containing 39
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Ribonucleoprotein Complex	Mitochondrion Cytosol
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding	Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein Trimerization Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Apoptotic Process Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: APC CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF8 MNAT1 NIF3L1 RBCK1 RNF111 SKP2 TRIM27 TRIM39 TRIM5 TRIM8 TROVE2 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 YWHAZ	52 interactors: APP CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 KDM1A LNX1 LXN MED18 MNAT1 OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMD9 RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1 UBTD2 UBXN1 UBXN6 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		6737	56658
HPRD ID		00170	09298
Ensembl ID		ENSG00000132109	ENSG00000204599
Uniprot IDs		P19474	Q9HCM9
PDB IDs		2IWG	2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Modification Process Proteolysis Regulation Of Protein Ubiquitination Protein Metabolic Process Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Mitotic Cell Cycle Innate Immune Response Cell Cycle Process Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cell Communication Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Ligase Activity Response To Stimulus	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Activation Of Innate Immune Response
Tagcloud ?		2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate	293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish
Tagcloud (Difference) ?		2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate	293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish
Tagcloud (Intersection) ?