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TRIM21 and IKBKB
Number of citations of the paper that reports this interaction (PubMedID
19675099
)
48
Data Source:
BioGRID
(enzymatic study, enzymatic study)
TRIM21
IKBKB
Description
tripartite motif containing 21
inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Cytosol
Cytoplasmic Stress Granule
SCF Ubiquitin Ligase Complex
Cytoplasmic Vesicle
Ribonucleoprotein Complex
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Biological Process
Autophagosome Assembly
Protein Polyubiquitination
Protein Monoubiquitination
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Proteasomal Protein Catabolic Process
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Binding
Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Stress Granule Assembly
Response To Type II Interferon
Stress Granule Disassembly
Protein K27-linked Ubiquitination
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Cell Cycle
Negative Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Viral Entry Into Host Cell
Protein Autoubiquitination
Cellular Response To Chemical Stress
Pyroptotic Inflammatory Response
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Protein Deubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Pathways
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
Interferon gamma signaling
KEAP1-NFE2L2 pathway
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
Lung cancer (
28604730
)
Malaria (
31844061
)
Interacting Genes
86 interacting genes:
AGO4
AIFM2
ALOX15B
APC
ATG5
CASP8AP2
CBX4
CDC34
CDKN1A
CLSPN
CUL1
CWC25
DAXX
DCP2
DLGAP1-AS2
DMAP1
DZIP3
EHHADH
ELAVL1
EXOC8
FADD
FBXW11
FHOD1
G3BP1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GRAP
HLA-DRB1
IGFN1
IGHG1
IGHV4-31
IKBKB
IRF5
IRF8
LNX1
LPP
MAP1LC3A
MAP1LC3B
MAP1LC3C
MNAT1
NAT8
NIF3L1
PFKP
PPP1CA
RAB11FIP1
RAB11FIP5
RNF111
RO60
SAMHD1
SETD7
SIRT5
SKP2
STK3
TBK1
TCP11L1
TNS4
TP53
TRIM27
TRIM3
TRIM39
TRIM5
TRIM8
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G2
UBE2I
UBE2L3
UBE2N
UBE2V1
UBE2W
USP15
USP2
USP4
VPS9D1
WEE2-AS1
XAF1
YJU2
YWHAZ
ZBTB16
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
Entrez ID
6737
3551
HPRD ID
00170
04462
Ensembl ID
ENSG00000132109
ENSG00000104365
Uniprot IDs
P19474
A0A499FJS7
G3V105
O14920
PDB IDs
2IWG
5JPX
5OLM
6FGA
6S53
7BBD
8A58
8Y58
8Y59
8Y5B
9QBA
3BRT
3BRV
4E3C
4KIK
8OMV
Enriched GO Terms of Interacting Partners
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Post-translational Protein Modification
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Protein Modification Process
Protein Ubiquitination
Cellular Response To Nitrogen Starvation
Cytosol
Ubiquitin Protein Ligase Binding
Cellular Response To Nutrient Levels
Catabolic Process
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Phosphatidylethanolamine Binding
Protein Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Response To Nutrient Levels
Mitophagy
Response To Stress
Cellular Response To Stress
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Defense Response To Virus
Cytoplasm
Cellular Response To Starvation
Autophagosome Organization
Macromolecule Metabolic Process
Protein K48-linked Ubiquitination
Autophagy Of Mitochondrion
Regulation Of Protein Ubiquitination
Nucleus
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Virus
Proteolysis
Response To Starvation
Vacuole Organization
Positive Regulation Of Protein Polyubiquitination
Autophagosome Assembly
TORC1 Signaling
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Post-translational Protein Modification
Defense Response To Other Organism
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Metabolic Process
Transferase Activity
Positive Regulation Of Protein Ubiquitination
PML Body
Protein K63-linked Ubiquitination
Macroautophagy
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
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Tagcloud (Intersection)
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