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CUL1 and FBH1
Number of citations of the paper that reports this interaction (PubMedID
11956208
)
0
Data Source:
HPRD
(in vivo)
CUL1
FBH1
Description
cullin 1
F-box DNA helicase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Chromatin
Nucleus
Chromosome
SCF Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Double-stranded DNA Binding
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
DNA Translocase Activity
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
3'-5' DNA Helicase Activity
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Lysosome Organization
Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Oxidative Stress
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Antiviral Innate Immune Response
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Protein Phosphorylation
DNA Repair
DNA Catabolic Process
DNA Damage Response
Protein Ubiquitination
Replication Fork Processing
Response To Intra-S DNA Damage Checkpoint Signaling
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Interacting Genes
62 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CEBPA
CENPE
CENPW
CFLAR
CFTR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
DVL2
E2F1
EIF4ENIF1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
FBXW8
GHR
GPS1
HIPK2
HOOK1
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
12 interacting genes:
CUL1
DSCR9
ESR1
PCNA
PIM2
RAD51
RBX1
RNF20
RPL13A
SKP1
UBC
ZDHHC17
Entrez ID
8454
84893
HPRD ID
04389
06243
Ensembl ID
ENSG00000055130
ENSG00000134452
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
B3KV95
F6UZG9
Q2TAK1
Q8NFZ0
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8CAF
8CDJ
8CDK
8OR0
8OR2
8OR3
8OR4
8UA6
8UBT
8UBU
8VVY
9JKB
9KBD
8F5Q
Enriched GO Terms of Interacting Partners
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Protein Modification By Small Protein Conjugation
SCF Ubiquitin Ligase Complex
Post-translational Protein Modification
Protein Modification Process
Protein Metabolic Process
Protein Neddylation
Macromolecule Metabolic Process
Cytosol
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Nucleus
Nucleoplasm
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Deneddylation
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Protein K48-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Intracellular Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
NEDD8 Ligase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Neddylation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Protein Monoubiquitination
Ubiquitin-like Ligase-substrate Adaptor Activity
Cullin Family Protein Binding
Positive Regulation Of Signal Transduction
Protein Destabilization
Intracellular Signal Transduction
Regulation Of Protein Modification Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Epithelial Cell Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
Macromolecule Metabolic Process
Protein Monoubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
SCF Ubiquitin Ligase Complex
Ubiquitin Ligase Complex Scaffold Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Modification-dependent Protein Catabolic Process
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Protein Modification Process
Protein Ubiquitination
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Binding
Cullin-RING Ubiquitin Ligase Complex
Protein K48-linked Ubiquitination
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
DNA Polymerase Binding
Cullin Family Protein Binding
Mitotic Cell Cycle Phase Transition
Post-translational Protein Modification
Cell Cycle Phase Transition
Protein Metabolic Process
Cellular Response To Radiation
Positive Regulation Of Autophagy
Regulation Of Programmed Cell Death
Chromatin Binding
Nuclear Estrogen Receptor Binding
Replication Fork Processing
Cellular Response To Oxidative Stress
Macromolecule Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Male Germ Cell Nucleus
PCNA Complex
Replisome
Response To Glucoside
Perforant Pathway To Dendrate Granule Cell Synapse
Negative Regulation Of Formation Of Translation Preinitiation Complex
Histone H2B C-terminal K Residue Ubiquitin Ligase Activity
Cellular Response To Chemical Stress
Proteolysis
Lysosome Organization
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Catabolic Process
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Tagcloud (Intersection)
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