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CUL1 and RBX1
Number of citations of the paper that reports this interaction (PubMedID
11961546
)
0
Data Source:
HPRD
(in vitro)
CUL1
RBX1
Description
cullin 1
ring-box 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Cul4-RING E3 Ubiquitin Ligase Complex
Site Of DNA Damage
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Metal Ion Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Biological Process
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Lysosome Organization
Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Oxidative Stress
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Antiviral Innate Immune Response
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Autophagosome Assembly
G1/S Transition Of Mitotic Cell Cycle
MAPK Cascade
Protein Polyubiquitination
Mitophagy
Epithelial To Mesenchymal Transition
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Lysosome Organization
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Insulin Receptor Signaling Pathway
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Protein Catabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Cellular Response To Insulin Stimulus
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To UV
MiRNA-mediated Gene Silencing By MRNA Destabilization
P38MAPK Cascade
TORC1 Signaling
T Cell Activation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Positive Regulation Of Translation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Cellular Response To Chemical Stress
Renal Sodium Ion Absorption
Protein K48-linked Ubiquitination
Cellular Response To Amino Acid Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Cellular Response To Insulin Stimulus
Negative Regulation Of Mitophagy
Negative Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Autoubiquitination
Negative Regulation Of Response To Oxidative Stress
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Potential therapeutics for SARS
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Interacting Genes
62 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CEBPA
CENPE
CENPW
CFLAR
CFTR
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
DVL2
E2F1
EIF4ENIF1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
FBXW8
GHR
GPS1
HIPK2
HOOK1
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
78 interacting genes:
APP
ARIH1
ARIH2
CAND1
CAND2
CCND1
CCNK
CDC34
CFLAR
COPS4
COPS6
CSNK1E
CUL1
CUL3
CUL4A
CUL4B
CUL5
CUL7
ELOB
ELOC
ERBIN
ERCC8
FBH1
FBXL2
FBXO45
FBXW8
FRZB
GHR
GLMN
GPS1
HAX1
KCTD17
KEAP1
KLHDC2
KLHL22
KLHL3
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
NEURL2
OS9
PBX4
PML
PRAME
RHOBTB3
RNF126
RPS6KB1
SERTAD1
SKP1
SMAD3
SNAI1
TAB1
TRIM27
TRIM74
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2F
UBE2G1
UBE2G2
UBE2H
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2R2
VHL
VRK2
Entrez ID
8454
9978
HPRD ID
04389
06794
Ensembl ID
ENSG00000055130
ENSG00000100387
Uniprot IDs
A0A090N7U0
B3KTW0
Q13616
P62877
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
7B5L
7B5M
7B5N
7B5R
7B5S
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8CAF
8CDJ
8CDK
8OR0
8OR2
8OR3
8OR4
8UA6
8UBT
8UBU
8VVY
9JKB
9KBD
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
7B5L
7B5M
7B5N
7B5S
7OKQ
7PLO
7Z8B
7Z8R
7Z8T
7Z8V
7ZBW
7ZBZ
8B3G
8B3I
8CDJ
8CDK
8GQ6
8H33
8H34
8H35
8H36
8H37
8H38
8H3A
8H3F
8H3Q
8H3R
8IJ1
8JAQ
8JAS
8JAV
8JE1
8K9I
8KHP
8OR0
8OR2
8OR3
8OR4
8PQL
8Q7E
8Q7H
8Q7R
8QU8
8R5H
8RHZ
8RWZ
8RX0
8UBU
8WDK
8WQA
8WQB
8WQC
8WQE
8WQF
8WQG
8WQH
9JKB
9KBD
Enriched GO Terms of Interacting Partners
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Protein Modification By Small Protein Conjugation
SCF Ubiquitin Ligase Complex
Post-translational Protein Modification
Protein Modification Process
Protein Metabolic Process
Protein Neddylation
Macromolecule Metabolic Process
Cytosol
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Nucleus
Nucleoplasm
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Deneddylation
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Protein K48-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Intracellular Signal Transduction
Cul7-RING Ubiquitin Ligase Complex
NEDD8 Ligase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Neddylation
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Protein Monoubiquitination
Ubiquitin-like Ligase-substrate Adaptor Activity
Cullin Family Protein Binding
Positive Regulation Of Signal Transduction
Protein Destabilization
Intracellular Signal Transduction
Regulation Of Protein Modification Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Modification Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Protein Metabolic Process
Proteasomal Protein Catabolic Process
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Catabolic Process
Ubiquitin-protein Transferase Activity
Macromolecule Metabolic Process
Cullin-RING Ubiquitin Ligase Complex
Protein Monoubiquitination
Cytosol
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Nucleus
Protein K11-linked Ubiquitination
Regulation Of Protein Metabolic Process
Cul2-RING Ubiquitin Ligase Complex
G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Stress
Ubiquitin-like Protein Transferase Activity
Cell Cycle G1/S Phase Transition
Cell Cycle Phase Transition
Transferase Activity
SCF Ubiquitin Ligase Complex
Nucleoplasm
Cytoplasm
Response To Stress
Protein K63-linked Ubiquitination
Mitotic Cell Cycle Phase Transition
Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
ATP Binding
Cul3-RING Ubiquitin Ligase Complex
Protein Binding
Regulation Of Intracellular Signal Transduction
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of TORC1 Signaling
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Tagcloud (Intersection)
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