TRIM21 and HLA-DRB1

Number of citations of the paper that reports this interaction (PMID 18022694)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TRIM21	HLA-DRB1
Gene Name		tripartite motif containing 21	major histocompatibility complex, class II, DR beta 1
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Ribonucleoprotein Complex	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein Trimerization Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways		Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Arthritis (juvenile idiopathic) ( 18576341) Cervical cancer ( 23482656) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) IgA nephropathy ( 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Leishmaniasis (visceral) ( 23291585) Lumiracoxib-related liver injury ( 20639878) Lymphoma ( 23349640) Multiple sclerosis ( 22190364 19525953 19525955 18941528) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nodular sclerosis Hodgkin lymphoma ( 22086417) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Response to ximelagatran treatment ( 17505501) Rheumatoid arthritis ( 21452313 17804836 18794853 17554300 20453841 20453842) Schizophrenia ( 23212062) Systemic lupus erythematosus ( 23273568 19838193) Systemic sclerosis ( 21779181) Type 1 diabetes ( 17632545) Ulcerative colitis ( 23128233 21297633 19122664 23511034)
Protein-Protein Interactions		37 interactors: APC CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF8 MNAT1 NIF3L1 RBCK1 RNF111 SKP2 TRIM27 TRIM39 TRIM5 TRIM8 TROVE2 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 YWHAZ	9 interactors: CTAG1B HLA-DMA HLA-DRA MAGEA3 MARCH1 TRA TRB TRIM21 ZDHHC17
Entrez ID		6737	3123
HPRD ID		00170	08349
Ensembl ID		ENSG00000132109	ENSG00000196126
Uniprot IDs		P19474	D7RIH8 P01911 P01912 Q29974 Q5Y7D1
PDB IDs		2IWG	1A6A 1BX2 1YMM 2WBJ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Modification Process Proteolysis Regulation Of Protein Ubiquitination Protein Metabolic Process Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Mitotic Cell Cycle Innate Immune Response Cell Cycle Process Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cell Communication Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Ligase Activity Response To Stimulus	Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Interferon-gamma-mediated Signaling Pathway Immune System Process Cellular Response To Interferon-gamma Polysaccharide Assembly With MHC Class II Protein Complex Response To Interferon-gamma Protein Polyubiquitination Negative Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Activation Protein Complex Assembly Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Deubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Thymic T Cell Selection Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Viral Release From Host Cell Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Lipoprotein Transport Regulation Of Viral Entry Into Host Cell Magnesium Ion Transport Cellular Component Assembly Thymic T Cell Selection Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Cellular Protein Metabolic Process Response To Stimulus Protein Destabilization Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein Palmitoylation Protein Modification By Small Protein Conjugation Regulation Of Cell Adhesion Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response
Tagcloud ?		2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate
Tagcloud (Difference) ?		2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate
Tagcloud (Intersection) ?