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KAT2A and HIST2H4A
Number of citations of the paper that reports this interaction (PMID
16096645
)
39
Data Source:
BioGRID
(enzymatic study)
KAT2A
HIST2H4A
Gene Name
K(lysine) acetyltransferase 2A
histone cluster 2, H4a
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
STAGA Complex
Transcription Factor TFTC Complex
Mitotic Spindle
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
H3 Histone Acetyltransferase Activity
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
In Utero Embryonic Development
Somitogenesis
Neural Tube Closure
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Cell Proliferation
Viral Process
Histone Deubiquitination
Telencephalon Development
Metencephalon Development
Midbrain Development
Regulation Of Protein Stability
Multicellular Organism Growth
Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HATs acetylate histones
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Pre-NOTCH Transcription and Translation
Signaling by NOTCH1
Pre-NOTCH Expression and Processing
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Chromatin organization
RNA Polymerase I Transcription
Signaling by NOTCH
Notch-HLH transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
45 interactors:
ATXN7
BATF2
BRCA1
CDK2
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
GATA2
HIST1H1B
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H3
HIST4H4
HSD11B2
IRF1
IRF2
IRF7
MYB
MYC
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RBPJ
RELA
SIRT2
SUMO1
TACC1
TACC2
TACC3
TADA2A
TCF3
TRRAP
XRCC6
27 interactors:
ATAD2
BRD4
BRDT
DNMT3L
EP300
HAT1
HIST1H3A
HIST2H2AC
KAT2A
KAT5
LBR
NAP1L4
PRMT1
PTMA
RAD51B
RBBP4
RNF20
RPS6KA5
SET
TAF15
TBL1X
TBL1XR1
TP53BP1
UBC
UCHL5
UHRF1
YWHAQ
Entrez ID
2648
8370
HPRD ID
03807
11821
Ensembl ID
ENSG00000108773
ENSG00000183941
Uniprot IDs
Q92830
B2R4R0
P62805
PDB IDs
1F68
1Z4R
3D7C
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Chromosome Organization
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To Stress
Gene Expression
Cell Cycle
Chromatin Organization
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Chromatin Silencing At RDNA
Regulation Of Cell Differentiation
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Type I Interferon Production
Organelle Organization
Regulation Of Metabolic Process
Immune System Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Type I Interferon Production
Negative Regulation Of Cell Differentiation
Chromatin Modification
DNA Methylation On Cytosine
Response To Abiotic Stimulus
Regulation Of Histone Modification
Chromatin Silencing
Regulation Of Chromosome Organization
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription, DNA-templated
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
RNA Biosynthetic Process
Protein Acetylation
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
DNA Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Positive Regulation Of Cellular Metabolic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Assembly
Histone H4 Acetylation
Peptidyl-lysine Modification
DNA Methylation On Cytosine
Chromatin Assembly Or Disassembly
Positive Regulation Of Metabolic Process
Tagcloud
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Difference)
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Intersection)
?