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KAT2A and CUL2
Number of citations of the paper that reports this interaction (PubMedID
19339690
)
38
Data Source:
BioGRID
(pull down, affinity chromatography technology)
KAT2A
CUL2
Description
lysine acetyltransferase 2A
cullin 2
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
SAGA Complex
Chromatin
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytoskeleton
Transcription Factor TFTC Complex
Oxoglutarate Dehydrogenase Complex
Mitotic Spindle
ATAC Complex
Nucleus
Nucleoplasm
Nucleolus
Cytosol
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Nuclear Lumen
Molecular Function
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
N-acetyltransferase Activity
Histone H3 Acetyltransferase Activity
Acetyltransferase Activity
Transferase Activity
Acyltransferase Activity
Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups
Protein Phosphatase Binding
Histone Deacetylase Binding
Histone H3K9 Acetyltransferase Activity
Histone H3K18 Acetyltransferase Activity
Histone H4K12 Acetyltransferase Activity
Protein-lysine-acetyltransferase Activity
Histone Succinyltransferase Activity
Peptide Glutaryltransferase Activity
Histone Glutaryltransferase Activity
DNA-binding Transcription Factor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Somitogenesis
Positive Regulation Of Cytokine Production
Neural Tube Closure
Gluconeogenesis
Regulation Of DNA Repair
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Heart Development
Long-term Memory
Regulation Of Gene Expression
Internal Peptidyl-lysine Acetylation
Telencephalon Development
Metencephalon Development
Midbrain Development
Positive Regulation Of Cell Projection Organization
Regulation Of Protein Stability
Response To Nutrient Levels
Multicellular Organism Growth
Protein Modification Process
Regulation Of RNA Splicing
Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Negative Regulation Of Centriole Replication
Fibroblast Proliferation
Regulation Of Synaptic Plasticity
Intracellular Distribution Of Mitochondria
Regulation Of T Cell Activation
Regulation Of Cell Division
Regulation Of Cell Cycle
Limb Development
Regulation Of Cartilage Development
Regulation Of Small Molecule Metabolic Process
Cellular Response To Tumor Necrosis Factor
Peptidyl-lysine Glutarylation
Regulation Of Bone Development
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Cardiac Muscle Cell Differentiation
G1/S Transition Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RNA Polymerase I Transcription Initiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Cardiogenesis
Formation of WDR5-containing histone-modifying complexes
Formation of paraxial mesoderm
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Neddylation
Regulation of expression of SLITs and ROBOs
Antigen processing: Ubiquitination & Proteasome degradation
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Coenzyme A
Diseases
GWAS
Coronary artery disease (
29212778
33020668
)
Inflammatory bowel disease (
26278503
)
Mean reticulocyte volume (
32888494
)
Vitiligo (
27723757
)
vWF and FVIII levels (
30586737
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Interacting Genes
67 interacting genes:
AKT1
ATXN7
BATF2
BECN1
CCND2
CCNE1
CDK2
CDK6
CDKN2B
CEBPA
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
ECHS1
EID1
EP300
FZR1
GATA2
GRM1
H1-5
H2AC20
H2AC4
H2BC21
H2BC3
H3-4
H3C1
H3C14
H4C14
H4C16
H4C7
HSD11B2
IRF1
IRF2
IRF7
KDELR2
LATS2
MAP2K3
MAPK14
MYB
MYC
NF2
NOTCH1
PBX1
PRKDC
PYGO2
RASSF1
RBPJ
RELA
RPA1
SIRT2
SNCA
STK11
TACC1
TACC2
TACC3
TADA2A
TCF3
TP53
TRRAP
TSC1
TTYH2
UBE2I
XRCC6
28 interacting genes:
ARID1B
CAND1
CDC34
COMMD1
COPS5
DCUN1D2
DCUN1D3
DCUN1D4
DCUN1D5
E2F1
ELOC
FNIP1
GPS1
KAT2A
KHNYN
MKNK2
NEDD8
RNF7
SAP130
SENP8
TRIP12
UBC
UBE2D1
UBE2D3
UBE2M
VHL
ZER1
ZYG11B
Entrez ID
2648
8453
HPRD ID
03807
06786
Ensembl ID
ENSG00000108773
ENSG00000108094
Uniprot IDs
Q92830
A0A0A0MTN0
A0A140VKB1
A0A8I5KVR3
B7Z1Y1
Q13617
PDB IDs
1F68
1Z4R
3D7C
5H84
5H86
5MLJ
5TRL
5TRM
6J3P
8E6O
8H65
8H66
8H6C
8H6D
4WQO
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
7PLO
8IJ1
8JAL
8JAQ
8JAR
8JAS
8JAU
8JAV
8JE1
8JE2
8PQL
8Q7R
8QU8
8R5H
8RWZ
8RX0
8WDK
8WQA
8WQB
8WQC
8WQE
8WQF
8WQG
8WQH
Enriched GO Terms of Interacting Partners
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Nucleus
Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Cell Population Proliferation
Structural Constituent Of Chromatin
Nucleosome
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Development
Regulation Of Transcription By RNA Polymerase II
Chromatin Remodeling
Chromatin Organization
Transcription Regulator Complex
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
DNA Binding
Negative Regulation Of Metabolic Process
Regulation Of Cell Cycle Process
Chromatin Binding
Regulation Of RNA Metabolic Process
Regulation Of Cell Differentiation
Protein Heterodimerization Activity
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Hemopoiesis
DNA-binding Transcription Factor Binding
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Transcription By RNA Polymerase II
Leukocyte Differentiation
Negative Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Metabolic Process
Regulation Of Multicellular Organismal Development
Mitotic Cell Cycle Phase Transition
Mononuclear Cell Differentiation
Nucleosome Assembly
Regulation Of Nucleobase-containing Compound Metabolic Process
Response To UV
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Cell Cycle Phase Transition
Chromosome
Protein Neddylation
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of Protein Neddylation
Protein Modification Process
Ubiquitin-like Protein Binding
Positive Regulation Of Protein Neddylation
Protein Metabolic Process
Cullin Family Protein Binding
Proteolysis Involved In Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Proteolysis
Cul2-RING Ubiquitin Ligase Complex
Regulation Of Primary Metabolic Process
Ubiquitin Ligase Complex
Nucleus
Modification-dependent Protein Catabolic Process
Positive Regulation Of Post-translational Protein Modification
Macromolecule Metabolic Process
Protein Ubiquitination
Ubiquitin Conjugating Enzyme Binding
Regulation Of Macromolecule Metabolic Process
Protein Deneddylation
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Modification Process
Nucleoplasm
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-protein Transferase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Metabolic Process
Macromolecule Catabolic Process
NEDD8 Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Proteasomal Protein Catabolic Process
Positive Regulation Of Metabolic Process
DeNEDDylase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Catabolic Process
Protein Polyubiquitination
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Tag Activity
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