KAT2A and TADA2A

Number of citations of the paper that reports this interaction (PMID 8972232)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		KAT2A	TADA2A
Gene Name		K(lysine) acetyltransferase 2A	transcriptional adaptor 2A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle	PCAF Complex Nucleus Chromosome
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific)	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Histone Acetyltransferase Activity Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Chromatin Organization Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Viral Process Histone Deubiquitination Telencephalon Development Metencephalon Development Midbrain Development Regulation Of Protein Stability Multicellular Organism Growth Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation	Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Histone H3 Acetylation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Ovarian cancer ( 23535730)
Protein-Protein Interactions		45 interactors: ATXN7 BATF2 BRCA1 CDK2 CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 GATA2 HIST1H1B HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HSD11B2 IRF1 IRF2 IRF7 MYB MYC NOTCH1 PBX1 PPARG PRKDC PYGO2 RBPJ RELA SIRT2 SUMO1 TACC1 TACC2 TACC3 TADA2A TCF3 TRRAP XRCC6	34 interactors: ARNT2 C1orf109 CCHCR1 CDCA7L EIF4E2 EXOC8 FAM107A FAM127C FARS2 FBF1 GPSM3 HGS KAT2A KLC4 KLHL38 KPNA2 LOC149950 MAGOH MCPH1 MFAP1 MTX2 MYC NR3C1 PPP1R16B PRKAB2 PRPF31 SF3A3 TADA3 TCF3 TEKT4 TTC23 TTC9C ZFYVE26 ZNF564
Entrez ID		2648	6871
HPRD ID		03807	03784
Ensembl ID		ENSG00000108773	ENSG00000108264
Uniprot IDs		Q92830	O75478
PDB IDs		1F68 1Z4R 3D7C	1X41
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cell Cycle Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Organelle Organization Regulation Of Metabolic Process Immune System Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Cell Differentiation Chromatin Modification DNA Methylation On Cytosine Response To Abiotic Stimulus Regulation Of Histone Modification Chromatin Silencing Regulation Of Chromosome Organization	Histone H3 Acetylation Gene Expression RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Histone Acetylation Heterocycle Metabolic Process Internal Peptidyl-lysine Acetylation Cellular Aromatic Compound Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Protein Stability Cellular Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated Cytoplasmic Transport RNA Biosynthetic Process Chromatin Organization Regulation Of Gluconeogenesis Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Glucocorticoid Mediated Signaling Pathway Exocyst Assembly Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Histone H4 Acetylation Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Organelle Organization Positive Regulation Of Cell Proliferation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Peptidyl-serine Dephosphorylation Fibroblast Apoptotic Process Protein Localization To Organelle Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Intracellular Steroid Hormone Receptor Signaling Pathway Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Regulation Of Chromosome Condensation Regulation Of Metabolic Process Cellular Protein Localization Cellular Localization
Tagcloud ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast
Tagcloud (Difference) ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast
Tagcloud (Intersection) ?