KAT2A and HSD11B2

Number of citations of the paper that reports this interaction (PubMedID 12878208)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		KAT2A	HSD11B2
Description		lysine acetyltransferase 2A	hydroxysteroid 11-beta dehydrogenase 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex SAGA Complex Chromatin Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle ATAC Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Phosphatase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone Glutaryltransferase Activity DNA-binding Transcription Factor Binding	Steroid Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NAD Binding 11-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Heart Development Long-term Memory Regulation Of Gene Expression Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Multicellular Organism Growth Protein Modification Process Regulation Of RNA Splicing Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Fibroblast Proliferation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Regulation Of Cell Division Regulation Of Cell Cycle Limb Development Regulation Of Cartilage Development Regulation Of Small Molecule Metabolic Process Cellular Response To Tumor Necrosis Factor Peptidyl-lysine Glutarylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation	Response To Hypoxia Regulation Of Blood Volume By Renal Aldosterone Lipid Metabolic Process Female Pregnancy Steroid Metabolic Process Glucocorticoid Metabolic Process Response To Xenobiotic Stimulus Response To Food Response To Insulin Cortisol Metabolic Process Response To Steroid Hormone Response To Glucocorticoid
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm	Glucocorticoid biosynthesis Prednisone ADME
Drugs		Coenzyme A	NADH Fluoxymesterone Formebolone Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate
Diseases			Apparent mineralocorticoid excess syndrome; 11-beta-ketoreductase deficiency
GWAS		Coronary artery disease ( 29212778 33020668) Inflammatory bowel disease ( 26278503) Mean reticulocyte volume ( 32888494) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)	Empathy quotient ( 29527006) Refractive error ( 32231278) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		67 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPA CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL ECHS1 EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-4 H3C1 H3C14 H4C14 H4C16 H4C7 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PRKDC PYGO2 RASSF1 RBPJ RELA RPA1 SIRT2 SNCA STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6	2 interacting genes: KAT2A KAT2B
Entrez ID		2648	3291
HPRD ID		03807	01958
Ensembl ID		ENSG00000108773	ENSG00000176387
Uniprot IDs		Q92830	P80365
PDB IDs		1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P 8E6O 8H65 8H66 8H6C 8H6D
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Nucleosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Protein Heterodimerization Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Mitotic Cell Cycle Phase Transition Mononuclear Cell Differentiation Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cell Cycle Phase Transition Chromosome	Histone H3K9 Acetyltransferase Activity Negative Regulation Of Centriole Replication Internal Peptidyl-lysine Acetylation Histone H3 Acetyltransferase Activity Internal Protein Amino Acid Acetylation Negative Regulation Of Centrosome Duplication Peptidyl-lysine Acetylation ATAC Complex Acetyltransferase Activity Histone Acetyltransferase Complex SAGA Complex Positive Regulation Of Gluconeogenesis Regulation Of Centriole Replication Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Positive Regulation Of Glucose Metabolic Process Gluconeogenesis Regulation Of Centrosome Duplication Regulation Of Gluconeogenesis Limb Development Regulation Of Centrosome Cycle Hexose Biosynthetic Process Regulation Of Embryonic Development Regulation Of Glucose Metabolic Process Carbohydrate Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process Memory Glucose Metabolic Process Histone Deacetylase Binding Mitotic Spindle Acyltransferase Activity Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Small Molecule Metabolic Process Hexose Metabolic Process Regulation Of RNA Splicing Regulation Of Cell Division Monosaccharide Metabolic Process Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity DNA-binding Transcription Factor Binding Peptide Glutaryltransferase Activity Regulation Of DNA Repair Regulation Of Organelle Assembly Regulation Of Microtubule-based Process Negative Regulation Of RRNA Processing Heart Development Learning Or Memory
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