KAT2A and HSD11B2

Number of citations of the paper that reports this interaction (PMID 12878208)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		KAT2A	HSD11B2
Gene Name		K(lysine) acetyltransferase 2A	hydroxysteroid (11-beta) dehydrogenase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle	Endoplasmic Reticulum
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific)	11-beta-hydroxysteroid Dehydrogenase [NAD(P)] Activity Steroid Binding NAD Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Chromatin Organization Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Viral Process Histone Deubiquitination Telencephalon Development Metencephalon Development Midbrain Development Regulation Of Protein Stability Multicellular Organism Growth Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation	Response To Hypoxia Regulation Of Blood Volume By Renal Aldosterone Glucocorticoid Biosynthetic Process Female Pregnancy Response To Food Response To Insulin Response To Drug Response To Glucocorticoid Oxidation-reduction Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ATXN7 BATF2 BRCA1 CDK2 CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 GATA2 HIST1H1B HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HSD11B2 IRF1 IRF2 IRF7 MYB MYC NOTCH1 PBX1 PPARG PRKDC PYGO2 RBPJ RELA SIRT2 SUMO1 TACC1 TACC2 TACC3 TADA2A TCF3 TRRAP XRCC6	2 interactors: KAT2A KAT2B
Entrez ID		2648	3291
HPRD ID		03807	01958
Ensembl ID		ENSG00000108773	ENSG00000176387
Uniprot IDs		Q92830	P80365
PDB IDs		1F68 1Z4R 3D7C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cell Cycle Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Organelle Organization Regulation Of Metabolic Process Immune System Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Cell Differentiation Chromatin Modification DNA Methylation On Cytosine Response To Abiotic Stimulus Regulation Of Histone Modification Chromatin Silencing Regulation Of Chromosome Organization	Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gluconeogenesis Positive Regulation Of Glucose Metabolic Process Histone H3 Acetylation Regulation Of Gluconeogenesis Regulation Of Glucose Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Carbohydrate Metabolic Process Chromatin Remodeling Peptidyl-lysine Modification Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation N-terminal Peptidyl-lysine Acetylation Histone Modification Histone H3-K14 Acetylation Regulation Of Cellular Ketone Metabolic Process Viral Process Chromatin Modification Histone H4-K12 Acetylation Regulation Of Protein Glycosylation Chromatin Organization N-terminal Protein Amino Acid Acetylation Transcription From RNA Polymerase II Promoter Histone Deubiquitination Peptidyl-amino Acid Modification Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Modification Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Initiation From RNA Polymerase I Promoter Regulation Of Glycoprotein Biosynthetic Process Transcription From RNA Polymerase I Promoter Histone H3-K9 Modification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H4 Acetylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Somitogenesis Midbrain Development Somite Development Neural Tube Closure Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	axes chem crh cyp11a1 cyp11b cyp19a1a eleutheroembryos environ esr1 fertilization fshb gnrh2 gnrh3 gonadal gonadogenesis hpa hpf hpg hypothalamic lhb norgestrel pomc pose setac star toxicol vtg1 zebrafish
Tagcloud (Difference) ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	axes chem crh cyp11a1 cyp11b cyp19a1a eleutheroembryos environ esr1 fertilization fshb gnrh2 gnrh3 gonadal gonadogenesis hpa hpf hpg hypothalamic lhb norgestrel pomc pose setac star toxicol vtg1 zebrafish
Tagcloud (Intersection) ?