KAT2A and PYGO2

Number of citations of the paper that reports this interaction (PMID 20937768)
10

Data Source:
BioGRID (pull down)

		KAT2A	PYGO2
Gene Name		K(lysine) acetyltransferase 2A	pygopus family PHD finger 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle	Nucleoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific)	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Chromatin Organization Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Viral Process Histone Deubiquitination Telencephalon Development Metencephalon Development Midbrain Development Regulation Of Protein Stability Multicellular Organism Growth Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation	In Utero Embryonic Development Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Post-embryonic Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Palate Development Canonical Wnt Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		45 interactors: ATXN7 BATF2 BRCA1 CDK2 CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 GATA2 HIST1H1B HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HSD11B2 IRF1 IRF2 IRF7 MYB MYC NOTCH1 PBX1 PPARG PRKDC PYGO2 RBPJ RELA SIRT2 SUMO1 TACC1 TACC2 TACC3 TADA2A TCF3 TRRAP XRCC6	5 interactors: BCL9 KAT2A NF2 SUPT3H TRRAP
Entrez ID		2648	90780
HPRD ID		03807	06065
Ensembl ID		ENSG00000108773	ENSG00000163348
Uniprot IDs		Q92830	Q5T170 Q9BRQ0
PDB IDs		1F68 1Z4R 3D7C	2XB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cell Cycle Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Organelle Organization Regulation Of Metabolic Process Immune System Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Cell Differentiation Chromatin Modification DNA Methylation On Cytosine Response To Abiotic Stimulus Regulation Of Histone Modification Chromatin Silencing Regulation Of Chromosome Organization	Histone Deubiquitination Protein Deubiquitination Histone Acetylation Internal Peptidyl-lysine Acetylation Protein Modification By Small Protein Removal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Peptidyl-lysine Modification Histone H3 Acetylation Histone Modification Histone H4 Acetylation Chromatin Modification Chromatin Organization Regulation Of Protein Stability Regulation Of Gene Expression Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Histone H3-K14 Acetylation Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Schwann Cell Proliferation Telencephalon Development Organelle Organization Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Hippo Signaling Histone H4-K12 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Histone H2A Acetylation Glial Cell Proliferation Regulation Of Metabolic Process Forebrain Development Tissue Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gluconeogenesis Growth Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ectoderm Development
Tagcloud ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Difference) ?		acetyltransferase antiviral correlates cytoplasm enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	catenin compartment converge depilation emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Intersection) ?		dispensable