KAT2A and PRKDC

Number of citations of the paper that reports this interaction (PMID 9488450)
29

Data Source:
BioGRID (enzymatic study)

		KAT2A	PRKDC
Gene Name		K(lysine) acetyltransferase 2A	protein kinase, DNA-activated, catalytic polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle	Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Nonhomologous End Joining Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific)	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Chromatin Organization Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Viral Process Histone Deubiquitination Telencephalon Development Metencephalon Development Midbrain Development Regulation Of Protein Stability Multicellular Organism Growth Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants	Nonhomologous End-joining (NHEJ) Cytosolic sensors of pathogen-associated DNA Processing of DNA ends prior to end rejoining STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ATXN7 BATF2 BRCA1 CDK2 CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 GATA2 HIST1H1B HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HSD11B2 IRF1 IRF2 IRF7 MYB MYC NOTCH1 PBX1 PPARG PRKDC PYGO2 RBPJ RELA SIRT2 SUMO1 TACC1 TACC2 TACC3 TADA2A TCF3 TRRAP XRCC6	83 interactors: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CHEK1 CHEK2 CHUK CIB1 CTDP1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 ERG GSK3A GSK3B GZMB H2AFX HDAC3 HIST1H1A HIST1H1C HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11A NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R2 PPP6R3 PRKCD PTS RAD17 RBBP8 RNF144A RPA1 RPA2 SGOL1 SP1 SRF THRA THRB TP53 TREX1 UBC USF1 VPRBP WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ
Entrez ID		2648	5591
HPRD ID		03807	02941
Ensembl ID		ENSG00000108773	ENSG00000253729
Uniprot IDs		Q92830	P78527
PDB IDs		1F68 1Z4R 3D7C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cell Cycle Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Organelle Organization Regulation Of Metabolic Process Immune System Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Cell Differentiation Chromatin Modification DNA Methylation On Cytosine Response To Abiotic Stimulus Regulation Of Histone Modification Chromatin Silencing Regulation Of Chromosome Organization	Cellular Response To Stress DNA Repair Cellular Response To DNA Damage Stimulus DNA Recombination DNA Metabolic Process Double-strand Break Repair Response To Stress Immune System Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Immune System Development Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cell Cycle Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Organelle Organization Cellular Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Cell Death Death Telomere Maintenance Developmental Process Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Organ Development Mitotic Cell Cycle Process
Tagcloud ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?