PARP1 and ETS1

Number of citations of the paper that reports this interaction (PubMedID 29912634)
0

Data Source:
BioGRID (pull down)

		PARP1	ETS1
Description		poly(ADP-ribose) polymerase 1	ETS proto-oncogene 1, transcription factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Nuclear Replication Fork Site Of DNA Damage	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding RNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Nucleosome Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Transcription Regulator Activator Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Immune System Process DNA Repair Double-strand Break Repair Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Carbohydrate Biosynthetic Process Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Mitochondrial DNA Repair Innate Immune Response Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Necroptotic Process Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Cellular Response To Zinc Ion Cellular Response To Transforming Growth Factor Beta Stimulus Replication Fork Reversal DNA Repair-dependent Chromatin Remodeling Negative Regulation Of CGAS/STING Signaling Pathway Transcription Pausing By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen-containing Compound Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Aldosterone Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Regulation Of Base-excision Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Site Of Double-strand Break ATP Generation From Poly-ADP-D-ribose Negative Regulation Of ATP Biosynthetic Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation PML Body Organization Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of MiRNA Transcription Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Oncogene Induced Senescence
Drugs		Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785 32109421) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480 32341527) Platelet count ( 29403010) Telomere length ( 29151059)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 20190752 22057235 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 31959993 30054594 29785010 29617998) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 27863252 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 30423114 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 20169177 23273568 28714469 27399966 26502338 26663301) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 30297969 30054458) Ulcerative colitis ( 28067908) White blood cell count ( 27863252 32888494)
Interacting Genes		123 interacting genes: AATF ANXA1 APTX ATM ATR BCL2 BGLT3 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CEBPA CENPA CENPB CTCF CTSB CTSG DTX2 DUX4 E2F1 E4F1 EPB41L2 ERBB2 ERCC6 ERG ETS1 FNDC3B FOXO1 GTF2F1 GZMB GZMM H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-4 H4C3 HDAC1 HDAC3 HECTD3 HIPK2 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LINC00624 LZTR1 MACROH2A1 MALAT1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 NUDT16 OGT OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF10 RNF144A RNF168 RNF4 RPS3A RSPH1 RXRA SENP1 SENP3 SMURF2 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 TP53BP1 TRIP12 UBE2I USP1 USP15 USP7 WEE2-AS1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	54 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREB1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 GGA1 GGA2 GGA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		142	2113
HPRD ID		01435	01260
Ensembl ID		ENSG00000143799	ENSG00000134954
Uniprot IDs		P09874	A8K725 B4DW78 P14921
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6M3I 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW 7AAA 7AAB 7AAC 7AAD 7CMW 7KK2 7KK3 7KK4 7KK5 7KK6 7ONR 7ONS 7ONT 7S68 7S6H 7S6M 7S81 7SCY 7SCZ 8FYY 8FYZ 8FZ1 8G0H 8HE7 8HLR 8JNZ 8U4W 9BPY 9CKC 9DMC 9ETQ 9ETR	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Chromosome Protein Modification Process Negative Regulation Of DNA Metabolic Process DNA Repair DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Chromatin Cellular Response To Stress Post-translational Protein Modification Negative Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Negative Regulation Of Cell Cycle Protein Localization To Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Transcription Regulator Complex	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Transcription Regulator Complex Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Identical Protein Binding Nucleus Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-templated Transcription Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Transcription Coactivator Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
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