PARP1 and CENPA

Number of citations of the paper that reports this interaction (PMID 12011073)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PARP1	CENPA
Gene Name		poly (ADP-ribose) polymerase 1	centromere protein A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Nucleolus Membrane	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding NAD Binding R-SMAD Binding	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance DNA Repair Base-excision Repair Double-strand Break Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein ADP-ribosylation Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation Cellular Response To Insulin Stimulus Regulation Of Growth Rate DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Protein Poly-ADP-ribosylation Cellular Response To Superoxide Positive Regulation Of Transcription Regulatory Region DNA Binding	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleosome Assembly Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs		Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3\'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Diseases
GWAS		Melanoma ( 21983785)
Protein-Protein Interactions		84 interactors: APLF APTX ATM BCL2 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTSB CTSG E2F1 ERCC6 ERG FOXO1 GTF2F1 GZMB GZMM H2AFY HDAC1 HDAC3 HIST1H1A HIST1H1C HIST1H2BA HIST1H4A HIST1H4C HIST2H2AA3 HMGA1 HOXB7 HSPA2 KAT2B LIG3 LZTR1 MED14 MED6 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POLB POU2F1 PRKDC RARA RBM14 RELA RNF146 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO1 SUMO2 SUPT16H SWAP70 TCF4 TP53 TRIM29 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	8 interactors: AURKB AURKC DIAPH1 DIAPH2 HIST1H3C HIST1H4F PARP1 PARP2
Entrez ID		142	1058
HPRD ID		01435	00313
Ensembl ID		ENSG00000143799	ENSG00000115163
Uniprot IDs		P09874	P49450
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S	3AN2 3NQJ 3NQU 3R45
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process DNA Repair Cellular Response To Stress Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Telomere Maintenance Negative Regulation Of Transcription, DNA-templated Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Gene Expression Apoptotic Signaling Pathway Base-excision Repair Regulation Of Apoptotic Process Biosynthetic Process Cellular Response To Stimulus Organelle Organization Response To Stimulus	Cellular Macromolecular Complex Assembly Protein Complex Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Protein Complex Assembly DNA Replication-dependent Nucleosome Assembly Spindle Midzone Assembly Cytokinesis Attachment Of Spindle Microtubules To Kinetochore Organelle Organization Cellular Component Assembly DNA Methylation On Cytosine Chromosome Organization Chromatin Silencing At RDNA Histone-serine Phosphorylation Mitotic Spindle Assembly Protein ADP-ribosylation Chromatin Organization Chromatin Silencing Positive Regulation Of Cytokinesis Histone Phosphorylation Actin Filament Polymerization Mitotic Spindle Organization Regulation Of Cytokinesis Microtubule Anchoring DNA Methylation Base-excision Repair Histone Modification DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Cytoskeleton Organization Cell Division Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Actin Polymerization Or Depolymerization Spindle Assembly DNA Modification Protein Polymerization Gene Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Peptidyl-serine Phosphorylation Nucleosome Assembly Positive Regulation Of Cell Division Spindle Organization Chromatin Modification Chromatin Assembly
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly
Tagcloud (Intersection) ?		instability