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PARP1 and HSPA2
Number of citations of the paper that reports this interaction (PubMedID
19607827
)
0
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
PARP1
HSPA2
Description
poly(ADP-ribose) polymerase 1
heat shock protein family A (Hsp70) member 2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Nuclear Replication Fork
Site Of DNA Damage
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Membrane
CatSper Complex
Extracellular Exosome
Blood Microparticle
Meiotic Spindle
Molecular Function
DNA Binding
Chromatin Binding
Damaged DNA Binding
RNA Binding
Catalytic Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Enzyme Activator Activity
Zinc Ion Binding
Transferase Activity
Glycosyltransferase Activity
Nucleotidyltransferase Activity
Enzyme Binding
Protein Kinase Binding
Nuclear Estrogen Receptor Binding
Nucleosome Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Metal Ion Binding
NAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Transcription Regulator Activator Activity
NAD+-protein-serine ADP-ribosyltransferase Activity
NAD+-protein-aspartate ADP-ribosyltransferase Activity
NAD+-protein-glutamate ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein Mono-ADP-ribosyltransferase Activity
Nucleotide Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Enzyme Binding
Heat Shock Protein Binding
Protein Folding Chaperone
Tau Protein Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Glycolipid Binding
ATP-dependent Protein Folding Chaperone
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Immune System Process
DNA Repair
Double-strand Break Repair
Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Carbohydrate Biosynthetic Process
Protein Autoprocessing
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Mitochondrial DNA Repair
Innate Immune Response
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Necroptotic Process
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Protein Localization To Chromatin
Cellular Response To Zinc Ion
Cellular Response To Transforming Growth Factor Beta Stimulus
Replication Fork Reversal
DNA Repair-dependent Chromatin Remodeling
Negative Regulation Of CGAS/STING Signaling Pathway
Transcription Pausing By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Oxygen-containing Compound
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Aldosterone
Negative Regulation Of Adipose Tissue Development
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Regulation Of Base-excision Repair
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Cellular Response To Nerve Growth Factor Stimulus
Protein Localization To Site Of Double-strand Break
ATP Generation From Poly-ADP-D-ribose
Negative Regulation Of ATP Biosynthetic Process
Protein Folding
Response To Unfolded Protein
Male Meiotic Nuclear Division
Male Meiosis I
Spermatogenesis
Spermatid Development
Response To Heat
Response To Cold
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cell Differentiation
Protein Refolding
Synaptonemal Complex Disassembly
Negative Regulation Of Inclusion Body Assembly
Pathways
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Meiotic synapsis
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
PKR-mediated signaling
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Quercetin
Diseases
GWAS
Coronary artery disease (
29212778
)
Leukocyte telomere length (
31171785
32109421
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Appendicular lean mass (
33097823
)
Interacting Genes
123 interacting genes:
AATF
ANXA1
APTX
ATM
ATR
BCL2
BGLT3
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CEBPA
CENPA
CENPB
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
E4F1
EPB41L2
ERBB2
ERCC6
ERG
ETS1
FNDC3B
FOXO1
GTF2F1
GZMB
GZMM
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-4
H4C3
HDAC1
HDAC3
HECTD3
HIPK2
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LINC00624
LZTR1
MACROH2A1
MALAT1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
NUDT16
OGT
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF10
RNF144A
RNF168
RNF4
RPS3A
RSPH1
RXRA
SENP1
SENP3
SMURF2
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
TP53BP1
TRIP12
UBE2I
USP1
USP15
USP7
WEE2-AS1
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
14 interacting genes:
APP
BAG4
CDK1
CRBN
EWSR1
FTCD
HSPBP1
MAP3K3
MEOX2
PARP1
RNF144A
SAE1
TRIM38
UBE3A
Entrez ID
142
3306
HPRD ID
01435
07174
Ensembl ID
ENSG00000143799
ENSG00000126803
Uniprot IDs
P09874
P54652
PDB IDs
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6M3I
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
7AAA
7AAB
7AAC
7AAD
7CMW
7KK2
7KK3
7KK4
7KK5
7KK6
7ONR
7ONS
7ONT
7S68
7S6H
7S6M
7S81
7SCY
7SCZ
8FYY
8FYZ
8FZ1
8G0H
8HE7
8HLR
8JNZ
8U4W
9BPY
9CKC
9DMC
9ETQ
9ETR
3I33
4FSV
5FPD
5FPE
5FPM
5FPN
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Chromatin Remodeling
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Chromosome
Protein Modification Process
Negative Regulation Of DNA Metabolic Process
DNA Repair
DNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Chromatin
Cellular Response To Stress
Post-translational Protein Modification
Negative Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Double-strand Break Repair
Negative Regulation Of Cell Cycle
Protein Localization To Chromosome
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle Process
Transcription Regulator Complex
Post-translational Protein Modification
Protein Modification Process
Regulation Of Protein Localization
Regulation Of Circadian Rhythm
Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Cytoplasm
Positive Regulation Of Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Adenyl-nucleotide Exchange Factor Activity
Transferase Activity
Protein Localization To Site Of Double-strand Break
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Protein Localization
Response To Copper Ion
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
Response To Nerve Growth Factor
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Amyloid-beta
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
Cellular Response To Nerve Growth Factor Stimulus
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Regulation Of Establishment Of Protein Localization
Amylin Binding
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Toll Signaling Pathway
Pronuclear Fusion
Limb Development
Sperm Entry
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Golgi Lumen Acidification
Negative Regulation Of MRNA Modification
Regulation Of Protein Targeting To Mitochondrion
Protein Sumoylation
Glutamate Formimidoyltransferase Activity
Formimidoyltetrahydrofolate Cyclodeaminase Activity
Modification-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Primary Metabolic Process
Response To Amyloid-beta
Positive Regulation Of Macromolecule Metabolic Process
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