PARP1 and CASP3

  • Number of citations of the paper that reports this interaction (PMID 19549685)
  • 34
  • Data Source:
  • BioGRID (enzymatic study)

PARP1

CASP3

Gene Name poly (ADP-ribose) polymerase 1 caspase 3, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 84 interactors: APLF APTX ATM BCL2 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTSB CTSG E2F1 ERCC6 ERG FOXO1 GTF2F1 GZMB GZMM H2AFY HDAC1 HDAC3 HIST1H1A HIST1H1C HIST1H2BA HIST1H4A HIST1H4C HIST2H2AA3 HMGA1 HOXB7 HSPA2 KAT2B LIG3 LZTR1 MED14 MED6 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POLB POU2F1 PRKDC RARA RBM14 RELA RNF146 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO1 SUMO2 SUPT16H SWAP70 TCF4 TP53 TRIM29 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423 153 interactors: ACIN1 ADD1 AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SOCS5 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16
Entrez ID 142 836
HPRD ID 01435 02799
Ensembl ID ENSG00000143799 ENSG00000164305
Uniprot IDs P09874 A8MVM1 P42574
PDB IDs 1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
ageing  ascribes  atm  attrition  brca1  complexity  ctip  ends  fusions  homologous  instability  insufficient  joining  ku70  lig3  lig4  mechanistically  nhej  overhang  rampant  relies  repeats  telomere  telomeres  telomeric  trf2  unanticipated  uncapped  underlining 
abeta1  accelerated  amyloid  apoe4  bace1  becomes  deposits  event  hallmark  hyperphosphorylation  increasingly  later  losses  nonetheless  nonsynonymous  nontransgenic  oxys  picalm  posits  precede  proof  psen1  psen2  snps  sorl1  sporadic  triggers  turn  unlikely 
Tagcloud (Difference) ?
ageing  ascribes  atm  attrition  brca1  complexity  ctip  ends  fusions  homologous  instability  insufficient  joining  ku70  lig3  lig4  mechanistically  nhej  overhang  rampant  relies  repeats  telomere  telomeres  telomeric  trf2  unanticipated  uncapped  underlining 
abeta1  accelerated  amyloid  apoe4  bace1  becomes  deposits  event  hallmark  hyperphosphorylation  increasingly  later  losses  nonetheless  nonsynonymous  nontransgenic  oxys  picalm  posits  precede  proof  psen1  psen2  snps  sorl1  sporadic  triggers  turn  unlikely 
Tagcloud (Intersection) ?