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PARP1 and ERCC6
Number of citations of the paper that reports this interaction (PubMedID
16107709
)
49
Data Source:
HPRD
(in vitro, in vivo)
PARP1
ERCC6
Description
poly(ADP-ribose) polymerase 1
ERCC excision repair 6, chromatin remodeling factor
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Nuclear Replication Fork
Site Of DNA Damage
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Transcription Elongation Factor Complex
Nuclear Body
Site Of DNA Damage
B-WICH Complex
Molecular Function
DNA Binding
Chromatin Binding
Damaged DNA Binding
RNA Binding
Catalytic Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Enzyme Activator Activity
Zinc Ion Binding
Transferase Activity
Glycosyltransferase Activity
Nucleotidyltransferase Activity
Enzyme Binding
Protein Kinase Binding
Nuclear Estrogen Receptor Binding
Nucleosome Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Metal Ion Binding
NAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Transcription Regulator Activator Activity
NAD+-protein-serine ADP-ribosyltransferase Activity
NAD+-protein-aspartate ADP-ribosyltransferase Activity
NAD+-protein-glutamate ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein Mono-ADP-ribosyltransferase Activity
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Chromatin Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
RNA Polymerase Binding
Chromatin-protein Adaptor Activity
ATP-dependent Chromatin Remodeler Activity
ATP-dependent DNA Damage Sensor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Immune System Process
DNA Repair
Double-strand Break Repair
Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Carbohydrate Biosynthetic Process
Protein Autoprocessing
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Mitochondrial DNA Repair
Innate Immune Response
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Necroptotic Process
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Protein Localization To Chromatin
Cellular Response To Zinc Ion
Cellular Response To Transforming Growth Factor Beta Stimulus
Replication Fork Reversal
DNA Repair-dependent Chromatin Remodeling
Negative Regulation Of CGAS/STING Signaling Pathway
Transcription Pausing By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Oxygen-containing Compound
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Aldosterone
Negative Regulation Of Adipose Tissue Development
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Regulation Of Base-excision Repair
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Cellular Response To Nerve Growth Factor Stimulus
Protein Localization To Site Of Double-strand Break
ATP Generation From Poly-ADP-D-ribose
Negative Regulation Of ATP Biosynthetic Process
Single Strand Break Repair
DNA Damage Checkpoint Signaling
Response To Superoxide
Positive Regulation Of Defense Response To Virus By Host
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Chromatin Remodeling
Transcription Elongation By RNA Polymerase I
Transcription By RNA Polymerase II
DNA Damage Response
Response To Oxidative Stress
JNK Cascade
Nervous System Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Positive Regulation Of Gene Expression
Protein Ubiquitination
Neurogenesis
Neuron Differentiation
Neuron Projection Development
Regulation Of DNA-templated Transcription Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Regulation Of Transcription Elongation By RNA Polymerase II
Multicellular Organism Growth
DNA Protection
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Transcription By RNA Polymerase I
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Protein Localization To Chromatin
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Cockayne syndrome
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Coronary artery disease (
29212778
)
Leukocyte telomere length (
31171785
32109421
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Interacting Genes
123 interacting genes:
AATF
ANXA1
APTX
ATM
ATR
BCL2
BGLT3
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CEBPA
CENPA
CENPB
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
E4F1
EPB41L2
ERBB2
ERCC6
ERG
ETS1
FNDC3B
FOXO1
GTF2F1
GZMB
GZMM
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-4
H4C3
HDAC1
HDAC3
HECTD3
HIPK2
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LINC00624
LZTR1
MACROH2A1
MALAT1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
NUDT16
OGT
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF10
RNF144A
RNF168
RNF4
RPS3A
RSPH1
RXRA
SENP1
SENP3
SMURF2
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
TP53BP1
TRIP12
UBE2I
USP1
USP15
USP7
WEE2-AS1
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
117 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
DCLRE1A
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
Entrez ID
142
2074
HPRD ID
01435
00596
Ensembl ID
ENSG00000143799
ENSG00000225830
Uniprot IDs
P09874
P0DP91
Q03468
Q59FF6
PDB IDs
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6M3I
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
7AAA
7AAB
7AAC
7AAD
7CMW
7KK2
7KK3
7KK4
7KK5
7KK6
7ONR
7ONS
7ONT
7S68
7S6H
7S6M
7S81
7SCY
7SCZ
8FYY
8FYZ
8FZ1
8G0H
8HE7
8HLR
8JNZ
8U4W
9BPY
9CKC
9DMC
9ETQ
9ETR
4CVO
6A6I
7OO3
7OOB
7OOP
7OPC
7OPD
8B3D
8B3F
9BZ0
9ER2
9FD2
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Chromatin Remodeling
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Chromosome
Protein Modification Process
Negative Regulation Of DNA Metabolic Process
DNA Repair
DNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Chromatin
Cellular Response To Stress
Post-translational Protein Modification
Negative Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Double-strand Break Repair
Negative Regulation Of Cell Cycle
Protein Localization To Chromosome
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle Process
Transcription Regulator Complex
Translation
Ribosome
Macromolecule Metabolic Process
RNA Binding
Macromolecule Biosynthetic Process
Structural Constituent Of Ribosome
Ribonucleoprotein Complex
Mitochondrial Translation
Nucleoplasm
Protein Metabolic Process
NuRD Complex
Mitochondrial Large Ribosomal Subunit
Mitochondrial Inner Membrane
Regulation Of Cell Fate Specification
Regulation Of Cell Fate Commitment
Nucleus
Protein-RNA Complex Assembly
Cytosolic Ribosome
Ubiquitin Protein Ligase Binding
Nucleic Acid Metabolic Process
PML Body
Regulation Of Stem Cell Differentiation
Small Protein Activating Enzyme Binding
Cytoplasmic Translation
Formation Of Cytoplasmic Translation Initiation Complex
Chromosome, Telomeric Region
Eukaryotic Translation Initiation Factor 3 Complex
Nucleobase-containing Compound Metabolic Process
Eukaryotic 48S Preinitiation Complex
Protein Sumoylation
Mitochondrion
Eukaryotic 43S Preinitiation Complex
Cytoplasmic Translational Initiation
Chromatin Organization
Protein-containing Complex
Nucleosomal DNA Binding
Nucleolus
DNA Repair
Chromatin Remodeling
Mitochondrial Ribosome
Regulation Of Protein Metabolic Process
Transcription-coupled Nucleotide-excision Repair
Translational Initiation
Nucleotide-excision Repair
Protein-containing Complex Organization
DNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Protein-containing Complex Assembly
Chromosome
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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