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PARP1 and NPM1
Number of citations of the paper that reports this interaction (PubMedID
39501047
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
PARP1
NPM1
Description
poly(ADP-ribose) polymerase 1
nucleophosmin 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Nuclear Replication Fork
Site Of DNA Damage
Granular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Focal Adhesion
Large Ribosomal Subunit
Small Ribosomal Subunit
Membrane
Nuclear Speck
Spindle Pole Centrosome
Protein-containing Complex
Protein-DNA Complex
Ribonucleoprotein Complex
Molecular Function
DNA Binding
Chromatin Binding
Damaged DNA Binding
RNA Binding
Catalytic Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Enzyme Activator Activity
Zinc Ion Binding
Transferase Activity
Glycosyltransferase Activity
Nucleotidyltransferase Activity
Enzyme Binding
Protein Kinase Binding
Nuclear Estrogen Receptor Binding
Nucleosome Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Metal Ion Binding
NAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Transcription Regulator Activator Activity
NAD+-protein-serine ADP-ribosyltransferase Activity
NAD+-protein-aspartate ADP-ribosyltransferase Activity
NAD+-protein-glutamate ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein Mono-ADP-ribosyltransferase Activity
Core Promoter Sequence-specific DNA Binding
Nucleic Acid Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
RRNA Binding
Protein Kinase Binding
Tat Protein Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
NF-kappaB Binding
Unfolded Protein Binding
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Immune System Process
DNA Repair
Double-strand Break Repair
Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Carbohydrate Biosynthetic Process
Protein Autoprocessing
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Mitochondrial DNA Repair
Innate Immune Response
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Necroptotic Process
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Protein Localization To Chromatin
Cellular Response To Zinc Ion
Cellular Response To Transforming Growth Factor Beta Stimulus
Replication Fork Reversal
DNA Repair-dependent Chromatin Remodeling
Negative Regulation Of CGAS/STING Signaling Pathway
Transcription Pausing By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Oxygen-containing Compound
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Aldosterone
Negative Regulation Of Adipose Tissue Development
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Regulation Of Base-excision Repair
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Cellular Response To Nerve Growth Factor Stimulus
Protein Localization To Site Of Double-strand Break
ATP Generation From Poly-ADP-D-ribose
Negative Regulation Of ATP Biosynthetic Process
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Regulation Of Cell Growth
DNA Repair
Nucleosome Assembly
Chromatin Remodeling
Protein Import Into Nucleus
Cell Volume Homeostasis
Intracellular Protein Transport
Nucleocytoplasmic Transport
Centrosome Cycle
Signal Transduction
Intracellular Protein Localization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Centrosome Duplication
Negative Regulation Of Centrosome Duplication
Macrophage Differentiation
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Endodeoxyribonuclease Activity
Cellular Response To UV
Regulation Of Cell Population Proliferation
Ribosome Biogenesis
Ribosome Assembly
Ribosomal Large Subunit Biogenesis
Ribosomal Small Subunit Biogenesis
Negative Regulation Of Apoptotic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Centriole Replication
Negative Regulation Of MRNA Splicing, Via Spliceosome
Protein Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Cellular Senescence
Regulation Of MRNA Stability Involved In Cellular Response To UV
Positive Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Protein Localization To Nucleolus
Pathways
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Nuclear import of Rev protein
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SARS-CoV-1-host interactions
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
PKR-mediated signaling
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Artenimol
Diseases
GWAS
Coronary artery disease (
29212778
)
Leukocyte telomere length (
31171785
32109421
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Brain morphology (MOSTest) (
32665545
)
Height (
28552196
)
Multisite chronic pain (
33830993
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
123 interacting genes:
AATF
ANXA1
APTX
ATM
ATR
BCL2
BGLT3
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CEBPA
CENPA
CENPB
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
E4F1
EPB41L2
ERBB2
ERCC6
ERG
ETS1
FNDC3B
FOXO1
GTF2F1
GZMB
GZMM
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-4
H4C3
HDAC1
HDAC3
HECTD3
HIPK2
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LINC00624
LZTR1
MACROH2A1
MALAT1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
NUDT16
OGT
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF10
RNF144A
RNF168
RNF4
RPS3A
RSPH1
RXRA
SENP1
SENP3
SMURF2
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
TP53BP1
TRIP12
UBE2I
USP1
USP15
USP7
WEE2-AS1
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
68 interacting genes:
ABCC1
ACY1
ALK
APP
ARF1
ATM
CACYBP
CD24
CDK1
CDK2
CDKN2A
CDT1
CENPW
CHEK1
CLK1
COX8A
CSNK2A1
DUX4
EIF2AK2
ELF4
EP300
ERG
ESR1
GADD45A
GGA1
GGA2
GGA3
GNAI2
GNL3
GRB2
GZMM
H2AC20
H2BC21
H3-4
HAND2
HMGA1
HMGA2
HOXA7
IRF1
IRS1
LINC01554
MDM2
NCL
NIBAN1
NOP2
OGT
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SIRT7
SP1
SREK1
SUMO2
TCERG1
TFAP2A
TP53
UBC
UQCRH
WEE2-AS1
XPO1
YY1
Entrez ID
142
4869
HPRD ID
01435
01246
Ensembl ID
ENSG00000143799
ENSG00000181163
Uniprot IDs
P09874
A0A0S2Z491
A0A0S2Z4G7
A0A140VJQ2
E5RI98
P06748
PDB IDs
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6M3I
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
7AAA
7AAB
7AAC
7AAD
7CMW
7KK2
7KK3
7KK4
7KK5
7KK6
7ONR
7ONS
7ONT
7S68
7S6H
7S6M
7S81
7SCY
7SCZ
8FYY
8FYZ
8FZ1
8G0H
8HE7
8HLR
8JNZ
8U4W
9BPY
9CKC
9DMC
9ETQ
9ETR
2LLH
2P1B
2VXD
5EHD
7OBG
7OBH
8AH2
8AS5
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Chromatin Remodeling
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Chromosome
Protein Modification Process
Negative Regulation Of DNA Metabolic Process
DNA Repair
DNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Chromatin
Cellular Response To Stress
Post-translational Protein Modification
Negative Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Double-strand Break Repair
Negative Regulation Of Cell Cycle
Protein Localization To Chromosome
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle Process
Transcription Regulator Complex
Positive Regulation Of Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Population Proliferation
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Signal Transduction In Response To DNA Damage
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Regulation Of Programmed Cell Death
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Protein Catabolic Process
Response To Stress
Protein Localization To Organelle
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Gene Expression
Cellular Response To Oxygen-containing Compound
Chromatin Binding
Protein Localization To Site Of Double-strand Break
Negative Regulation Of DNA Metabolic Process
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Tagcloud (Intersection)
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