ARHGAP28 and MTNR1A

Number of citations: 0 (PubMedID 26514267)
Data Source: BioGRID (two hybrid)

		ARHGAP28	MTNR1A
Name		Rho GTPase activating protein 28	melatonin receptor 1A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cell Junction	Plasma Membrane Membrane Receptor Complex
	Molecular Function	GTPase Activator Activity	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding
	Biological Process	Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm
Pathways		RHOA GTPase cycle	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		None	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Diffusing capacity of carbon monoxide ( 30694715 ) General risk tolerance (MTAG) ( 30643258 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Resting-state electroencephalogram vigilance ( 29703947 )	Depressive symptoms measurement (somatic complaints domain) ( 26997408 ) Job-related exhaustion in shift workers ( 28364478 ) Mild obesity-related type 2 diabetes ( 34737425 ) Obesity ( 21552555 )
Interacting Genes		3 interacting genes: HSPB1 MTNR1A MTNR1B	160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460
Entrez ID		79822	4543
HPRD ID		10961	02812
Ensembl ID		ENSG00000088756	ENSG00000168412
Uniprot IDs		B4DXL2 Q9P2N2	P48039
PDB IDs		Not available	6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
GO Terms Enriched among Interactors		Melatonin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity G Protein-coupled Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Transport Along Microtubule Contractile Muscle Fiber Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Positive Regulation Of Endothelial Cell Chemotaxis Hormone Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Transmission Of Nerve Impulse Mating Behavior Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Protein Refolding Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Behavior Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Reproductive Behavior G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Anterograde Axonal Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Protein Kinase C Binding Platelet Aggregation	Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity