ARHGAP28

Name	Rho GTPase activating protein 28
Structure	No pdb structure
Interactors	3 interactors: HSPB1 MTNR1A MTNR1B
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cell Junction
	Molecular Function	GTPase Activator Activity
	Biological Process	Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly
Pathways	RHOA GTPase cycle
GWAS	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Diffusing capacity of carbon monoxide ( 30694715 ) General risk tolerance (MTAG) ( 30643258 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Resting-state electroencephalogram vigilance ( 29703947 )
Entrez ID	79822
HPRD ID	10961
Ensembl ID	ENSG00000088756
Uniprot IDs	B4DXL2 Q9P2N2
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Melatonin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity G Protein-coupled Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Transport Along Microtubule Contractile Muscle Fiber Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Positive Regulation Of Endothelial Cell Chemotaxis Hormone Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Transmission Of Nerve Impulse Mating Behavior Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Protein Refolding Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Behavior Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Reproductive Behavior G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Anterograde Axonal Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Protein Kinase C Binding Platelet Aggregation