ARHGAP28

Description		Rho GTPase activating protein 28
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cell Junction
	Molecular Function	GTPase Activator Activity
	Biological Process	Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly
Pathways		RHOA GTPase cycle
Drugs
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Diffusing capacity of carbon monoxide ( 30694715) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Resting-state electroencephalogram vigilance ( 29703947)
Interacting Genes		3 interacting genes: HSPB1 MTNR1A MTNR1B
Entrez ID		79822
HPRD ID		10961
Ensembl ID		ENSG00000088756
Uniprot IDs		B4DXL2 Q9P2N2
PDB IDs
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Kinase C Signaling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity G Protein-coupled Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Transport Along Microtubule Contractile Muscle Fiber Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Positive Regulation Of Endothelial Cell Chemotaxis Hormone Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Transmission Of Nerve Impulse Mating Behavior Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Protein Refolding Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Behavior Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Reproductive Behavior G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Anterograde Axonal Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Protein Kinase C Binding Platelet Aggregation
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